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small amount of undiluted C3F8
C3F8 (perfluoropropane) is an expansile gas used in vitreoretinal surgery to provide internal tamponade and support retinal reattachment.
C3F8 (perfluoropropane) is an expansile gas used in vitreoretinal surgery to provide internal tamponade and support retinal reattachment. Used for Rhegmatogenous retinal detachment with superior breaks, Complex retinal detachment with proliferative vitreoretinopathy, Retinal detachment associated with macular hole.
At a glance
| Generic name | small amount of undiluted C3F8 |
|---|---|
| Sponsor | Universidade Federal de Pernambuco |
| Drug class | Perfluorocarbon gas (surgical tamponade agent) |
| Modality | Small molecule |
| Therapeutic area | Ophthalmology |
| Phase | FDA-approved |
Mechanism of action
C3F8 is a perfluorocarbon gas that expands to approximately 4 times its original volume over 6–8 weeks, creating a bubble that presses the detached retina back against the eye wall. This mechanical support allows the retinal pigment epithelium to reabsorb subretinal fluid and permits retinal breaks to heal. The gas is gradually absorbed and replaced by the eye's natural fluids.
Approved indications
- Rhegmatogenous retinal detachment with superior breaks
- Complex retinal detachment with proliferative vitreoretinopathy
- Retinal detachment associated with macular hole
Common side effects
- Elevated intraocular pressure
- Cataract formation or progression
- Corneal opacification
- Refractive shift (myopia)
- Epiretinal membrane formation
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
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