{"id":"small-amount-of-undiluted-c3f8","safety":{"commonSideEffects":[{"rate":null,"effect":"Elevated intraocular pressure"},{"rate":null,"effect":"Cataract formation or progression"},{"rate":null,"effect":"Corneal opacification"},{"rate":null,"effect":"Refractive shift (myopia)"},{"rate":null,"effect":"Epiretinal membrane formation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"C3F8 is a perfluorocarbon gas that expands to approximately 4 times its original volume over 6–8 weeks, creating a bubble that presses the detached retina back against the eye wall. This mechanical support allows the retinal pigment epithelium to reabsorb subretinal fluid and permits retinal breaks to heal. The gas is gradually absorbed and replaced by the eye's natural fluids.","oneSentence":"C3F8 (perfluoropropane) is an expansile gas used in vitreoretinal surgery to provide internal tamponade and support retinal reattachment.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:08:30.231Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Rhegmatogenous retinal detachment with superior breaks"},{"name":"Complex retinal detachment with proliferative vitreoretinopathy"},{"name":"Retinal detachment associated with macular hole"}]},"trialDetails":[{"nctId":"NCT04527848","phase":"PHASE4","title":"Comparison of Two Intraocular Gas Injection Techniques in Macula Hole Surgery","status":"COMPLETED","sponsor":"Universidade Federal de Pernambuco","startDate":"2016-05-10","conditions":"Macular Holes","enrollment":48}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"small amount of undiluted C3F8","genericName":"small amount of undiluted C3F8","companyName":"Universidade Federal de Pernambuco","companyId":"universidade-federal-de-pernambuco","modality":"Small molecule","firstApprovalDate":"","aiSummary":"C3F8 (perfluoropropane) is an expansile gas used in vitreoretinal surgery to provide internal tamponade and support retinal reattachment. Used for Rhegmatogenous retinal detachment with superior breaks, Complex retinal detachment with proliferative vitreoretinopathy, Retinal detachment associated with macular hole.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}