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Slit One ragweed
Slit One ragweed is a sublingual immunotherapy that desensitizes the immune system to ragweed allergen through gradual exposure under the tongue.
Slit One ragweed is a sublingual immunotherapy that desensitizes the immune system to ragweed allergen through gradual exposure under the tongue. Used for Ragweed pollen-induced allergic rhinitis and/or allergic asthma.
At a glance
| Generic name | Slit One ragweed |
|---|---|
| Also known as | Slitone (Alk Abello) |
| Sponsor | ASST Fatebenefratelli Sacco |
| Drug class | Sublingual immunotherapy (SLIT) |
| Target | Ragweed allergen (Amb a 1 and related epitopes) |
| Modality | Biologic |
| Therapeutic area | Immunology / Allergy |
| Phase | Phase 3 |
Mechanism of action
This is an allergen immunotherapy product designed to induce immune tolerance to ragweed pollen by delivering small, gradually increasing doses of ragweed allergen extract sublingually. The mechanism involves shifting the immune response from Th2-mediated allergic inflammation toward Th1/Treg-mediated tolerance, reducing allergic symptoms upon natural allergen exposure.
Approved indications
- Ragweed pollen-induced allergic rhinitis and/or allergic asthma
Common side effects
- Oral pruritus
- Throat irritation
- Mouth edema
- Local allergic reactions
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |