{"id":"slit-one-ragweed","safety":{"commonSideEffects":[{"rate":null,"effect":"Oral pruritus"},{"rate":null,"effect":"Throat irritation"},{"rate":null,"effect":"Mouth edema"},{"rate":null,"effect":"Local allergic reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"This is an allergen immunotherapy product designed to induce immune tolerance to ragweed pollen by delivering small, gradually increasing doses of ragweed allergen extract sublingually. The mechanism involves shifting the immune response from Th2-mediated allergic inflammation toward Th1/Treg-mediated tolerance, reducing allergic symptoms upon natural allergen exposure.","oneSentence":"Slit One ragweed is a sublingual immunotherapy that desensitizes the immune system to ragweed allergen through gradual exposure under the tongue.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:53:17.667Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Ragweed pollen-induced allergic rhinitis and/or allergic asthma"}]},"trialDetails":[{"nctId":"NCT01500642","phase":"PHASE3","title":"Comparison of the Efficacy and the Safety of Different Schedules of Administration of Sub-lingual Immunotherapy","status":"COMPLETED","sponsor":"ASST Fatebenefratelli Sacco","startDate":"2011-06","conditions":"Pollen Allergy","enrollment":45}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":20,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Slitone (Alk Abello)"],"phase":"phase_3","status":"active","brandName":"Slit One ragweed","genericName":"Slit One ragweed","companyName":"ASST Fatebenefratelli Sacco","companyId":"asst-fatebenefratelli-sacco","modality":"Biologic","firstApprovalDate":"","aiSummary":"Slit One ragweed is a sublingual immunotherapy that desensitizes the immune system to ragweed allergen through gradual exposure under the tongue. Used for Ragweed pollen-induced allergic rhinitis and/or allergic asthma.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}