Last reviewed 2026-04-23 · How we verify

Skin Xenotransplant

A bioengineered porcine skin xenotransplant provides temporary or permanent replacement of damaged or missing human skin through cross-species tissue grafting.

A bioengineered porcine skin xenotransplant provides temporary or permanent replacement of damaged or missing human skin through cross-species tissue grafting. Used for Severe thermal burns, Chronic wounds, Acute wound coverage.

At a glance

Mechanism of action

Skin xenotransplants utilize genetically modified porcine (pig) skin tissue to serve as a biological dressing or permanent graft for severe burn wounds, chronic wounds, or other conditions requiring skin replacement. The xenogeneic tissue is processed to minimize immunogenic rejection while providing structural support, barrier function, and biological activity to promote wound healing and tissue regeneration.

Approved indications

• Severe thermal burns
• Chronic wounds
• Acute wound coverage

Common side effects

• Graft rejection
• Infection
• Inflammatory response

Key clinical trials

• Gender Affirming Vaginoplasty With Tubularized Augmented Peritoneal Cap (TAPCap) Utilizing Fish Skin Xenograft (Kerecis™)
• Safety and Efficacy of realSKIN® to Provide Complete Wound Closure of Burn Wounds as an Alternative to Autografting (PHASE3)
• Kerecis Fish Skin Grafts With and Without Platelet Rich Plasma (PRP) (NA)
• Evaluation of Safety and Efficacy of realSKIN® (Skin Xenotransplant) for Complete Closure of Severe Burn Wounds (PHASE1, PHASE2)
• Porcine Xenograft Versus Second Intention Healing (NA)
• Methods Validation Assessment for Study of Inflammatory Skin Disease
• Scarring At Donor Sites After Split-Thickness Skin Graft.
• PORCINE XENOGRAFT OR MICROBIAL CELLULOSE IN THE TREATMENT OF PARTIAL THICKNESS BURNS (NA)

Primary sources

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