{"id":"skin-xenotransplant","safety":{"commonSideEffects":[{"rate":null,"effect":"Graft rejection"},{"rate":null,"effect":"Infection"},{"rate":null,"effect":"Inflammatory response"}]},"_chembl":{"chemblId":"CHEMBL2109200","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Skin xenotransplants utilize genetically modified porcine (pig) skin tissue to serve as a biological dressing or permanent graft for severe burn wounds, chronic wounds, or other conditions requiring skin replacement. The xenogeneic tissue is processed to minimize immunogenic rejection while providing structural support, barrier function, and biological activity to promote wound healing and tissue regeneration.","oneSentence":"A bioengineered porcine skin xenotransplant provides temporary or permanent replacement of damaged or missing human skin through cross-species tissue grafting.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:53:07.328Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Severe thermal burns"},{"name":"Chronic wounds"},{"name":"Acute wound coverage"}]},"trialDetails":[{"nctId":"NCT07286123","phase":"","title":"Gender Affirming Vaginoplasty With Tubularized Augmented Peritoneal Cap (TAPCap) Utilizing Fish Skin Xenograft (Kerecis™)","status":"RECRUITING","sponsor":"University Hospitals Cleveland Medical Center","startDate":"2025-07-22","conditions":"Gender Dysphoria, Adult","enrollment":20},{"nctId":"NCT06223269","phase":"PHASE3","title":"Safety and Efficacy of realSKIN® to Provide Complete Wound Closure of Burn Wounds as an Alternative to Autografting","status":"RECRUITING","sponsor":"XenoTherapeutics, Inc.","startDate":"2024-05-09","conditions":"Burns Degree Third, Burn (Disorder), Burn Degree Second","enrollment":50},{"nctId":"NCT05766982","phase":"NA","title":"Kerecis Fish Skin Grafts With and Without Platelet Rich Plasma (PRP)","status":"WITHDRAWN","sponsor":"St Elizabeth Healthcare","startDate":"2024-01-30","conditions":"Non-healing Wound","enrollment":""},{"nctId":"NCT03695939","phase":"PHASE1, PHASE2","title":"Evaluation of Safety and Efficacy of realSKIN® (Skin Xenotransplant) for Complete Closure of Severe Burn Wounds","status":"COMPLETED","sponsor":"XenoTherapeutics, Inc.","startDate":"2019-03-15","conditions":"Deep Full-thickness Burn Injury (Disorder)","enrollment":25},{"nctId":"NCT03931746","phase":"NA","title":"Porcine Xenograft Versus Second Intention Healing","status":"TERMINATED","sponsor":"Northwell Health","startDate":"2019-06-11","conditions":"Wound Healing and Scar Quality Following Mohs Surgery and Excisional Dermatologic Surgery","enrollment":14},{"nctId":"NCT03796806","phase":"","title":"Methods Validation Assessment for Study of Inflammatory Skin Disease","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2019-01-14","conditions":"Lichen Planus","enrollment":1},{"nctId":"NCT04490213","phase":"","title":"Scarring At Donor Sites After Split-Thickness Skin Graft.","status":"COMPLETED","sponsor":"University Hospital, Linkoeping","startDate":"2018-06-15","conditions":"Donor Site Complication","enrollment":17},{"nctId":"NCT04412759","phase":"NA","title":"PORCINE XENOGRAFT OR MICROBIAL CELLULOSE IN THE TREATMENT OF PARTIAL THICKNESS BURNS","status":"COMPLETED","sponsor":"University Hospital, Linkoeping","startDate":"2016-06","conditions":"Burns, Burn Scar, Burn Second Degree","enrollment":26},{"nctId":"NCT04391582","phase":"PHASE2","title":"Pediatric Burn Treatment Using Tilapia Skin as a Xenograft for Superficial-Partial Thickness Wounds","status":"COMPLETED","sponsor":"Nucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara","startDate":"2017-05-01","conditions":"Burns","enrollment":30},{"nctId":"NCT04202289","phase":"PHASE3","title":"Use of Nile Tilapia Fish Skin as a Xenograft for Burn Treatment: Phase III Study","status":"COMPLETED","sponsor":"Nucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara","startDate":"2017-04-03","conditions":"Burns","enrollment":115},{"nctId":"NCT03113747","phase":"PHASE1, PHASE2","title":"Allogeneic ADSCs and Platelet-Poor Plasma Fibrin Hydrogel to Treat the Patients With Burn Wounds (ADSCs-BWs)","status":"UNKNOWN","sponsor":"A.A. Partners, LLC","startDate":"2015-03-25","conditions":"Second- or Third-degree Burns","enrollment":20},{"nctId":"NCT01655407","phase":"PHASE2","title":"Safety and Efficacy Study of Autologous Engineered Skin Substitute to Treat Partial- and Full-Thickness Burn Wounds","status":"UNKNOWN","sponsor":"Amarantus BioScience Holdings, Inc.","startDate":"2016-09","conditions":"Thermal Injury, Deep Partial-Thickness Burn, Full-Thickness Burn","enrollment":10}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["realSKIN®"],"phase":"phase_3","status":"active","brandName":"Skin Xenotransplant","genericName":"Skin Xenotransplant","companyName":"XenoTherapeutics, Inc.","companyId":"xenotherapeutics-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"A bioengineered porcine skin xenotransplant provides temporary or permanent replacement of damaged or missing human skin through cross-species tissue grafting. Used for Severe thermal burns, Chronic wounds, Acute wound coverage.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}