Last reviewed 2026-04-23 · How we verify

SHR8058 eye drops

SHR8058 is a selective TRPM8 channel antagonist that reduces ocular surface pain and irritation by blocking cold-sensitive ion channels in the eye.

SHR8058 is a selective TRPM8 channel antagonist that reduces ocular surface pain and irritation by blocking cold-sensitive ion channels in the eye. Used for Dry eye disease (DED) with neuropathic pain component.

At a glance

Mechanism of action

TRPM8 (Transient Receptor Potential Melastatin 8) channels are expressed on sensory nerve endings in the cornea and conjunctiva and are involved in neuropathic pain signaling. By antagonizing TRPM8, SHR8058 reduces abnormal pain signaling and neurogenic inflammation on the ocular surface, providing symptomatic relief in dry eye disease and related conditions.

Approved indications

• Dry eye disease (DED) with neuropathic pain component

Common side effects

• Ocular irritation
• Conjunctival hyperemia
• Eye discomfort

Key clinical trials

• Effect of SHR8058 on Signs and Symptoms of Dry Eye Disease Associated With Meibomian Gland Dysfunction (PHASE3)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.