{"id":"shr8058-eye-drops","safety":{"commonSideEffects":[{"rate":null,"effect":"Ocular irritation"},{"rate":null,"effect":"Conjunctival hyperemia"},{"rate":null,"effect":"Eye discomfort"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"TRPM8 (Transient Receptor Potential Melastatin 8) channels are expressed on sensory nerve endings in the cornea and conjunctiva and are involved in neuropathic pain signaling. By antagonizing TRPM8, SHR8058 reduces abnormal pain signaling and neurogenic inflammation on the ocular surface, providing symptomatic relief in dry eye disease and related conditions.","oneSentence":"SHR8058 is a selective TRPM8 channel antagonist that reduces ocular surface pain and irritation by blocking cold-sensitive ion channels in the eye.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:34:37.791Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dry eye disease (DED) with neuropathic pain component"}]},"trialDetails":[{"nctId":"NCT05515471","phase":"PHASE3","title":"Effect of SHR8058 on Signs and Symptoms of Dry Eye Disease Associated With Meibomian Gland Dysfunction","status":"COMPLETED","sponsor":"Jiangsu HengRui Medicine Co., Ltd.","startDate":"2021-02-04","conditions":"Treatment of Dry Eye Disease With Meibomian Gland Dysfunction","enrollment":312}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"SHR8058 eye drops","genericName":"SHR8058 eye drops","companyName":"Jiangsu HengRui Medicine Co., Ltd.","companyId":"jiangsu-hengrui-medicine-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"SHR8058 is a selective TRPM8 channel antagonist that reduces ocular surface pain and irritation by blocking cold-sensitive ion channels in the eye. Used for Dry eye disease (DED) with neuropathic pain component.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}