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Short storage RBC age
This investigational approach studies the transfusion of red blood cells stored for shorter periods to evaluate clinical outcomes and safety compared to standard storage protocols.
This investigational approach studies the transfusion of red blood cells stored for shorter periods to evaluate clinical outcomes and safety compared to standard storage protocols. Used for Evaluation of short-storage RBC transfusion in critically ill patients, Assessment in perioperative/surgical patient populations.
At a glance
| Generic name | Short storage RBC age |
|---|---|
| Sponsor | Washington University School of Medicine |
| Modality | Biologic |
| Therapeutic area | Hematology / Transfusion Medicine |
| Phase | Phase 3 |
Mechanism of action
Red blood cell storage lesion—biochemical and functional changes that occur during standard blood bank storage—may be mitigated by using fresher RBCs. This Phase 3 study investigates whether transfusing RBCs stored for shorter durations reduces adverse clinical outcomes, organ dysfunction, and mortality in critically ill or surgical patients compared to conventional storage practices.
Approved indications
- Evaluation of short-storage RBC transfusion in critically ill patients
- Assessment in perioperative/surgical patient populations
Common side effects
- Transfusion-related acute lung injury (TRALI)
- Transfusion-associated circulatory overload (TACO)
- Hemolytic transfusion reaction
- Infection/sepsis from transfusion
Key clinical trials
- Age of Blood in Children in Pediatric Intensive Care Units (PHASE3)
- RBC Transfusion in Severe Anemia With Lactic Acidosis (PHASE3)
- Effect of Blood Storage Age on the Resolution of Lactic Acidosis in Children With Severe Malarial Anemia at Mulago Hospital (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Short storage RBC age CI brief — competitive landscape report
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- Washington University School of Medicine portfolio CI