{"id":"short-storage-rbc-age","safety":{"commonSideEffects":[{"rate":null,"effect":"Transfusion-related acute lung injury (TRALI)"},{"rate":null,"effect":"Transfusion-associated circulatory overload (TACO)"},{"rate":null,"effect":"Hemolytic transfusion reaction"},{"rate":null,"effect":"Infection/sepsis from transfusion"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Red blood cell storage lesion—biochemical and functional changes that occur during standard blood bank storage—may be mitigated by using fresher RBCs. This Phase 3 study investigates whether transfusing RBCs stored for shorter durations reduces adverse clinical outcomes, organ dysfunction, and mortality in critically ill or surgical patients compared to conventional storage practices.","oneSentence":"This investigational approach studies the transfusion of red blood cells stored for shorter periods to evaluate clinical outcomes and safety compared to standard storage protocols.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:34:23.215Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Evaluation of short-storage RBC transfusion in critically ill patients"},{"name":"Assessment in perioperative/surgical patient populations"}]},"trialDetails":[{"nctId":"NCT01977547","phase":"PHASE3","title":"Age of Blood in Children in Pediatric Intensive Care Units","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2014-01","conditions":"Anemia","enrollment":1538},{"nctId":"NCT01586923","phase":"PHASE3","title":"RBC Transfusion in Severe Anemia With Lactic Acidosis","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2013-02","conditions":"Anemia","enrollment":290},{"nctId":"NCT01580111","phase":"NA","title":"Effect of Blood Storage Age on the Resolution of Lactic Acidosis in Children With Severe Malarial Anemia at Mulago Hospital","status":"COMPLETED","sponsor":"Makerere University","startDate":"2010-12","conditions":"Compare Blood Age for Transfusion","enrollment":74}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Short storage RBC age","genericName":"Short storage RBC age","companyName":"Washington University School of Medicine","companyId":"washington-university-school-of-medicine","modality":"Biologic","firstApprovalDate":"","aiSummary":"This investigational approach studies the transfusion of red blood cells stored for shorter periods to evaluate clinical outcomes and safety compared to standard storage protocols. Used for Evaluation of short-storage RBC transfusion in critically ill patients, Assessment in perioperative/surgical patient populations.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}