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sevoflurane-sufentanil balanced
A balanced anesthetic combination that pairs sevoflurane (volatile anesthetic) with sufentanil (opioid) to produce general anesthesia through CNS depression and analgesia.
A balanced anesthetic combination that pairs sevoflurane (volatile anesthetic) with sufentanil (opioid) to produce general anesthesia through CNS depression and analgesia. Used for General anesthesia for surgical procedures.
At a glance
| Generic name | sevoflurane-sufentanil balanced |
|---|---|
| Sponsor | Konkuk University Medical Center |
| Drug class | Balanced anesthetic combination |
| Target | GABA receptors (sevoflurane); mu-opioid receptors (sufentanil) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Sevoflurane is an inhaled volatile anesthetic that depresses CNS activity and reduces consciousness, while sufentanil is a potent synthetic opioid agonist at mu-opioid receptors that provides analgesia and enhances sedation. Together, they create a balanced anesthetic technique that reduces the required dose of each agent while maintaining hemodynamic stability and providing both hypnosis and pain relief during surgery.
Approved indications
- General anesthesia for surgical procedures
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Nausea and vomiting
- Emergence delirium
Key clinical trials
- Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy (NA)
- Differences in Speed of Recovery From Anesthesia for Intraoral Surgery (NA)
- Heart Rate Variability to Quantify General Anesthesia Depth
- Remifentanil Anesthesia and Postoperative BIS in Cardiac Surgery (NA)
- Recovery Profiles of Remifentanil-based Regimen for Cardiac Surgery (PHASE4)
- Hemodynamics and Vital Organ Function in Intracerebral Hemorrhage (NA)
- Myocardial Injury in Remifentanil-based Versus Sevoflurane-sufentanil Balanced Regimens in OPCAB Surgery (NA)
- Surgical Pleth Index (SPI) Guided Analgesia During Sevoflurane Anesthesia (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- sevoflurane-sufentanil balanced CI brief — competitive landscape report
- sevoflurane-sufentanil balanced updates RSS · CI watch RSS
- Konkuk University Medical Center portfolio CI