Last reviewed · How we verify
sevoflurane in step up concentration
Sevoflurane is a volatile anesthetic that enhances inhibitory neurotransmission and suppresses excitatory signaling in the central nervous system to produce anesthesia.
Sevoflurane is a volatile anesthetic that enhances inhibitory neurotransmission and suppresses excitatory signaling in the central nervous system to produce anesthesia. Used for General anesthesia for surgical procedures, Anesthesia induction and maintenance in pediatric patients.
At a glance
| Generic name | sevoflurane in step up concentration |
|---|---|
| Sponsor | University Hospital, Ghent |
| Drug class | Volatile general anesthetic |
| Target | GABA-A receptor, NMDA receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Sevoflurane acts as a general anesthetic by potentiating GABA-A receptors and inhibiting NMDA glutamate receptors, leading to depression of the central nervous system. The step-up concentration protocol involves gradually increasing the inspired concentration to facilitate smooth induction and reduce adverse hemodynamic effects. This titration approach is particularly useful in pediatric anesthesia and in patients at risk for cardiovascular instability.
Approved indications
- General anesthesia for surgical procedures
- Anesthesia induction and maintenance in pediatric patients
Common side effects
- Postoperative nausea and vomiting
- Emergence delirium
- Airway irritation
- Hypotension
- Bradycardia
- Hepatotoxicity (rare)
Key clinical trials
- Effect of Head Position on MACEI of Sevoflurane in Children With Obstructive Airway (NA)
- Is There an Adverse Drug Reaction Between Renin-Angiotensin System Blockade and Inhaled Anesthetics (PHASE4)
- Nitrous Oxide - Sevoflurane-Remifentanil Interaction (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- sevoflurane in step up concentration CI brief — competitive landscape report
- sevoflurane in step up concentration updates RSS · CI watch RSS
- University Hospital, Ghent portfolio CI