{"id":"sevoflurane-in-step-up-concentration","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Postoperative nausea and vomiting"},{"rate":"5-15","effect":"Emergence delirium"},{"rate":"5-10","effect":"Airway irritation"},{"rate":"variable","effect":"Hypotension"},{"rate":"variable","effect":"Bradycardia"},{"rate":"<1","effect":"Hepatotoxicity (rare)"}]},"_chembl":{"chemblId":"CHEMBL1200694","moleculeType":"Small molecule","molecularWeight":"200.05"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sevoflurane acts as a general anesthetic by potentiating GABA-A receptors and inhibiting NMDA glutamate receptors, leading to depression of the central nervous system. The step-up concentration protocol involves gradually increasing the inspired concentration to facilitate smooth induction and reduce adverse hemodynamic effects. This titration approach is particularly useful in pediatric anesthesia and in patients at risk for cardiovascular instability.","oneSentence":"Sevoflurane is a volatile anesthetic that enhances inhibitory neurotransmission and suppresses excitatory signaling in the central nervous system to produce anesthesia.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:07:41.968Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"General anesthesia for surgical procedures"},{"name":"Anesthesia induction and maintenance in pediatric patients"}]},"trialDetails":[{"nctId":"NCT03522402","phase":"NA","title":"Effect of Head Position on MACEI of Sevoflurane in Children With Obstructive Airway","status":"UNKNOWN","sponsor":"Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University","startDate":"2018-01-01","conditions":"Sevoflurane, Endotracheal Intubation","enrollment":38},{"nctId":"NCT01715584","phase":"PHASE4","title":"Is There an Adverse Drug Reaction Between Renin-Angiotensin System Blockade and Inhaled Anesthetics","status":"UNKNOWN","sponsor":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","startDate":"2012-07","conditions":"Hypertension","enrollment":80},{"nctId":"NCT01103193","phase":"PHASE4","title":"Nitrous Oxide - Sevoflurane-Remifentanil Interaction","status":"TERMINATED","sponsor":"University Hospital, Ghent","startDate":"2010-02","conditions":"ASA Class I/II Patients Scheduled for Surgery Under General Anesthesia","enrollment":4}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"sevoflurane in step up concentration","genericName":"sevoflurane in step up concentration","companyName":"University Hospital, Ghent","companyId":"university-hospital-ghent","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sevoflurane is a volatile anesthetic that enhances inhibitory neurotransmission and suppresses excitatory signaling in the central nervous system to produce anesthesia. Used for General anesthesia for surgical procedures, Anesthesia induction and maintenance in pediatric patients.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}