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Selective Nerve Root Block
A selective nerve root block is a minimally invasive injection procedure that delivers local anesthetic and/or corticosteroid directly to an inflamed nerve root to reduce pain and inflammation.
A selective nerve root block is a minimally invasive injection procedure that delivers local anesthetic and/or corticosteroid directly to an inflamed nerve root to reduce pain and inflammation. Used for Radicular pain from nerve root compression or inflammation, Cervical, thoracic, or lumbar radiculopathy.
At a glance
| Generic name | Selective Nerve Root Block |
|---|---|
| Sponsor | The Cleveland Clinic |
| Modality | Small molecule |
| Therapeutic area | Pain Management / Orthopedics |
| Phase | FDA-approved |
Mechanism of action
The procedure involves fluoroscopic or ultrasound guidance to precisely target a specific nerve root exiting the spinal column. By injecting anesthetic (which provides immediate pain relief) and corticosteroid (which reduces inflammation), the procedure aims to alleviate radicular pain and improve function. This is a therapeutic intervention rather than a systemically-acting drug.
Approved indications
- Radicular pain from nerve root compression or inflammation
- Cervical, thoracic, or lumbar radiculopathy
Common side effects
- Temporary increased pain
- Infection at injection site
- Bleeding or hematoma
- Dural puncture
- Transient neurological symptoms
Key clinical trials
- Ultrasound Guided Cervical Selective Nerve Root Block Versus Fluoroscopic Guided Cervical Transforaminal Epidural Block (NA)
- Multimodal Imaging and Biospecimen Collection for Low Back Pain (LBPB)
- Effectiveness Study of Physical Therapy As an Adjunct to a Lumbar Therapeutic Selective Nerve Root Block
- Comparing Local Anesthetic Techniques for Clavicular Surgeries (NA)
- Precision Treatment of Lumbar Spine Surgery Through Advanced Nerve Root Blockade (NA)
- Predicting Response to Interventional Pain Management Techniques in Chronic Low Back Pain in a Prospective Cohort.
- Paramedian CESI vs Selective Nerve Root PRF for Lower Cervical Radicular Pain (NA)
- Selective Cervical Root Block for Chronic Pain (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Selective Nerve Root Block CI brief — competitive landscape report
- Selective Nerve Root Block updates RSS · CI watch RSS
- The Cleveland Clinic portfolio CI