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Sedation Etomidate combined with propofol
A combination of two intravenous anesthetic agents that work synergistically to produce rapid sedation and hypnosis through GABAergic and other central nervous system pathways.
A combination of two intravenous anesthetic agents that work synergistically to produce rapid sedation and hypnosis through GABAergic and other central nervous system pathways. Used for Induction and maintenance of sedation in clinical settings, General anesthesia induction.
At a glance
| Generic name | Sedation Etomidate combined with propofol |
|---|---|
| Also known as | EP |
| Sponsor | RenJi Hospital |
| Drug class | Intravenous anesthetic combination |
| Target | GABA-A receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Etomidate is a non-barbiturate hypnotic that acts as a positive allosteric modulator of GABA-A receptors, producing rapid onset sedation with minimal respiratory depression. Propofol is an alkylphenol derivative that also enhances GABAergic inhibition and provides rapid induction of anesthesia. The combination leverages the rapid onset and hemodynamic stability of etomidate with the smooth induction profile of propofol.
Approved indications
- Induction and maintenance of sedation in clinical settings
- General anesthesia induction
Common side effects
- Hypotension
- Respiratory depression
- Bradycardia
- Injection site pain
- Apnea
Key clinical trials
- Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy (NA)
- SEdation Versus General Anesthesia for Endovascular Therapy in Acute Ischemic Stroke (PHASE4)
- Clonidine to Prevent Delirium After Electroconvulsive Therapy. (PHASE4)
- Etomidate Combined With Propofol Versus Propofol for Sedation in High-Altitude Patients During Gastroscopy: a Randomized Multicenter Clinical Trial (NA)
- EP Intravenous Anesthesia in Hysteroscopy (PHASE4)
- Nerve Block Anesthesia Combined With Sedative Anesthesia Versus General Anesthesia in Surgery for CSDH (NA)
- A Comparative Study of Rimazolam and Propofol Combined With Etomidate in Gastroenteroscopy in Elderly Patients (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Sedation Etomidate combined with propofol CI brief — competitive landscape report
- Sedation Etomidate combined with propofol updates RSS · CI watch RSS
- RenJi Hospital portfolio CI