{"id":"sedation-etomidate-combined-with-propofol","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Injection site pain"},{"rate":null,"effect":"Apnea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Etomidate is a non-barbiturate hypnotic that acts as a positive allosteric modulator of GABA-A receptors, producing rapid onset sedation with minimal respiratory depression. Propofol is an alkylphenol derivative that also enhances GABAergic inhibition and provides rapid induction of anesthesia. The combination leverages the rapid onset and hemodynamic stability of etomidate with the smooth induction profile of propofol.","oneSentence":"A combination of two intravenous anesthetic agents that work synergistically to produce rapid sedation and hypnosis through GABAergic and other central nervous system pathways.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:07:16.328Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Induction and maintenance of sedation in clinical settings"},{"name":"General anesthesia induction"}]},"trialDetails":[{"nctId":"NCT07460310","phase":"NA","title":"Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy","status":"NOT_YET_RECRUITING","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2026-03-01","conditions":"Ankle Sprain, Ankle (Ligaments); Instability (Old Injury), Pain Management","enrollment":200},{"nctId":"NCT03263117","phase":"PHASE4","title":"SEdation Versus General Anesthesia for Endovascular Therapy in Acute Ischemic Stroke","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2018-07-01","conditions":"Stroke","enrollment":260},{"nctId":"NCT04828226","phase":"PHASE4","title":"Clonidine to Prevent Delirium After Electroconvulsive Therapy.","status":"RECRUITING","sponsor":"Insel Gruppe AG, University Hospital Bern","startDate":"2021-04-27","conditions":"Major Depressive Disorder, Catatonia, Bipolar Disorder","enrollment":130},{"nctId":"NCT07079176","phase":"NA","title":"Etomidate Combined With Propofol Versus Propofol for Sedation in High-Altitude Patients During Gastroscopy: a Randomized Multicenter Clinical Trial","status":"NOT_YET_RECRUITING","sponsor":"RenJi Hospital","startDate":"2025-08-01","conditions":"Gastrointestinal Endoscopy","enrollment":732},{"nctId":"NCT05259787","phase":"PHASE4","title":"EP Intravenous Anesthesia in Hysteroscopy","status":"COMPLETED","sponsor":"RenJi Hospital","startDate":"2022-09-28","conditions":"Anesthesia","enrollment":366},{"nctId":"NCT05888389","phase":"NA","title":"Nerve Block Anesthesia Combined With Sedative Anesthesia Versus General Anesthesia in Surgery for CSDH","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2024-04-01","conditions":"Chronic Subdural Hematoma, Anesthesia","enrollment":190},{"nctId":"NCT05103696","phase":"NA","title":"A Comparative Study of Rimazolam and Propofol Combined With Etomidate in Gastroenteroscopy in Elderly Patients","status":"COMPLETED","sponsor":"Peking University People's Hospital","startDate":"2021-10-01","conditions":"Elderly Patients, Gastrointestinal Endoscopy, Remimazolam Besylate","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["EP"],"phase":"marketed","status":"active","brandName":"Sedation Etomidate combined with propofol","genericName":"Sedation Etomidate combined with propofol","companyName":"RenJi Hospital","companyId":"renji-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"A combination of two intravenous anesthetic agents that work synergistically to produce rapid sedation and hypnosis through GABAergic and other central nervous system pathways. Used for Induction and maintenance of sedation in clinical settings, General anesthesia induction.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}