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sclerotherapy with aethoxysclerol foam
Aethoxysclerol foam causes endothelial damage and thrombosis within varicose veins, leading to vessel fibrosis and obliteration.
Aethoxysclerol foam causes endothelial damage and thrombosis within varicose veins, leading to vessel fibrosis and obliteration. Used for Varicose veins of the lower extremities, Venous insufficiency.
At a glance
| Generic name | sclerotherapy with aethoxysclerol foam |
|---|---|
| Sponsor | Medical University of Vienna |
| Drug class | Sclerosing agent |
| Modality | Small molecule |
| Therapeutic area | Vascular/Dermatology |
| Phase | FDA-approved |
Mechanism of action
Aethoxysclerol is a sclerosing agent that, when injected as a foam into varicose veins, damages the venous endothelium and triggers an inflammatory response. This results in thrombosis and subsequent fibrosis of the vessel wall, causing the vein to close and be reabsorbed by the body. The foam formulation increases contact surface area with the endothelium, enhancing efficacy compared to liquid formulations.
Approved indications
- Varicose veins of the lower extremities
- Venous insufficiency
Common side effects
- Thrombophlebitis
- Hyperpigmentation at injection site
- Allergic reaction
- Matting (fine telangiectasia)
- Neovascularization
Key clinical trials
- Comparison of Radiofrequency Ablation With Concomitant or Staged Treatment for Tributary Varicose Veins (NA)
- Caprini Score in Venous Surgery: a Prospective Cohort Study
- Polidocanol Foam With or Without Transdermal Laser for Varicose Veins: Randomized Clinical Trial (NA)
- Efficacy of the SALFOAM 3% Method Compared to the Conventional Polidocanol Foam Method (Tessari Method) for Treating Lower Limb Varicose Veins (NA)
- Embolization Strategies for Pelvic Venous Disorders: Foam + Glue vs Foam + Coils (NA)
- Foam and Liquid Sclerotherapy With or Without Herbal Gel for Small Vein Treatment (NA)
- Laser Treatment of Reticular Leg Veins Vs. Sclerotherapy (NA)
- A Comparison of Flexible Endoscopic Polidocanol Liquid and Foam Sclerotherapy in Cirrhotic Patients With Bleeding From Internal Hemorrhoids (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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