{"id":"sclerotherapy-with-aethoxysclerol-foam","safety":{"commonSideEffects":[{"rate":null,"effect":"Thrombophlebitis"},{"rate":null,"effect":"Hyperpigmentation at injection site"},{"rate":null,"effect":"Allergic reaction"},{"rate":null,"effect":"Matting (fine telangiectasia)"},{"rate":null,"effect":"Neovascularization"}]},"_chembl":{"chemblId":"CHEMBL2107974","moleculeType":"Small molecule"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Aethoxysclerol is a sclerosing agent that, when injected as a foam into varicose veins, damages the venous endothelium and triggers an inflammatory response. This results in thrombosis and subsequent fibrosis of the vessel wall, causing the vein to close and be reabsorbed by the body. The foam formulation increases contact surface area with the endothelium, enhancing efficacy compared to liquid formulations.","oneSentence":"Aethoxysclerol foam causes endothelial damage and thrombosis within varicose veins, leading to vessel fibrosis and obliteration.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:07:07.452Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Varicose veins of the lower extremities"},{"name":"Venous insufficiency"}]},"trialDetails":[{"nctId":"NCT07445425","phase":"NA","title":"Comparison of Radiofrequency Ablation With Concomitant or Staged Treatment for Tributary Varicose Veins","status":"NOT_YET_RECRUITING","sponsor":"Sir Run Run Shaw Hospital","startDate":"2026-03","conditions":"Varicose Veins of Lower Limb","enrollment":206},{"nctId":"NCT03041805","phase":"","title":"Caprini Score in Venous Surgery: a Prospective Cohort Study","status":"RECRUITING","sponsor":"Pirogov Russian National Research Medical University","startDate":"2017-01-01","conditions":"Venous Thromboembolism, Varicose Veins","enrollment":3000},{"nctId":"NCT07276243","phase":"NA","title":"Polidocanol Foam With or Without Transdermal Laser for Varicose Veins: Randomized Clinical Trial","status":"NOT_YET_RECRUITING","sponsor":"Hospital Universitario Pedro Ernesto","startDate":"2026-01-01","conditions":"Varicose Veins","enrollment":102},{"nctId":"NCT06667570","phase":"NA","title":"Efficacy of the SALFOAM 3% Method Compared to the Conventional Polidocanol Foam Method (Tessari Method) for Treating Lower Limb Varicose Veins","status":"COMPLETED","sponsor":"Lidiane Rocha","startDate":"2024-10-25","conditions":"Varicose Veins","enrollment":35},{"nctId":"NCT07221695","phase":"NA","title":"Embolization Strategies for Pelvic Venous Disorders: Foam + Glue vs Foam + Coils","status":"ENROLLING_BY_INVITATION","sponsor":"Kafrelsheikh University","startDate":"2025-08-25","conditions":"Pelvic Congestive Syndrome","enrollment":60},{"nctId":"NCT07162844","phase":"NA","title":"Foam and Liquid Sclerotherapy With or Without Herbal Gel for Small Vein Treatment","status":"ACTIVE_NOT_RECRUITING","sponsor":"Kafrelsheikh University","startDate":"2024-09-05","conditions":"Telangectasia, Reticular Veins","enrollment":508},{"nctId":"NCT06175754","phase":"NA","title":"Laser Treatment of Reticular Leg Veins Vs. Sclerotherapy","status":"RECRUITING","sponsor":"Derzhavin Tambov State University","startDate":"2023-10-09","conditions":"Reticular Leg Veins","enrollment":174},{"nctId":"NCT06031740","phase":"NA","title":"A Comparison of Flexible Endoscopic Polidocanol Liquid and Foam Sclerotherapy in Cirrhotic Patients With Bleeding From Internal Hemorrhoids","status":"UNKNOWN","sponsor":"Institute of Liver and Biliary Sciences, India","startDate":"2023-09-07","conditions":"Liver Cirrhosis, Internal Hemorrhoid","enrollment":60},{"nctId":"NCT05807425","phase":"PHASE2, PHASE3","title":"Polidocanol Foam in Hemorrhoidal Disease in Patients With Liver Cirrhosis","status":"UNKNOWN","sponsor":"Universidade do Porto","startDate":"2023-03-31","conditions":"Hemorrhoids, Liver Cirrhosis","enrollment":40},{"nctId":"NCT03791775","phase":"PHASE2","title":"Efficacy and Safety of Polidocanol Foam 3% in the Treatment of II Degree Hemorrhoidal Disease","status":"COMPLETED","sponsor":"Societa Italiana di Chirurgia ColoRettale","startDate":"2019-01-02","conditions":"Second-degree Hemorrhoids","enrollment":183},{"nctId":"NCT04675177","phase":"PHASE2, PHASE3","title":"Polidocanol Foam VS Artery Ligation in Hemorrhoidal Disease","status":"COMPLETED","sponsor":"Universidade do Porto","startDate":"2019-09-01","conditions":"Hemorrhoids","enrollment":45},{"nctId":"NCT04091763","phase":"PHASE2","title":"Polidocanol Foam Versus Rubber Band Ligation in the Treatment of Hemorrhoidal Disease","status":"COMPLETED","sponsor":"Universidade do Porto","startDate":"2018-08-01","conditions":"Hemorrhoids, Internal","enrollment":120},{"nctId":"NCT04188171","phase":"PHASE2, PHASE3","title":"Sclerotherapy With Polidocanol Foam In The Treatment Of Hemorrhoidal Disease In Patients With Bleeding Disorders","status":"UNKNOWN","sponsor":"Universidade do Porto","startDate":"2018-08-01","conditions":"Hemorrhoids, Bleeding Disorder","enrollment":150},{"nctId":"NCT04398823","phase":"PHASE4","title":"A Multicenter Prospective Clinical Study of Endoscopic Foam Sclerotherapy for Internal Hemorrhoids","status":"UNKNOWN","sponsor":"Xinhua Hospital, Shanghai Jiao Tong University School of Medicine","startDate":"2020-05-15","conditions":"Grade/Stage I Hemorrhoids, Prolapsed Grade II Internal Haemorrhoid, Prolapsed Grade III Internal Haemorrhoid","enrollment":700},{"nctId":"NCT02753270","phase":"NA","title":"Catheter-directed Foam Sclerotherapy With Tumescence","status":"COMPLETED","sponsor":"University of Sao Paulo","startDate":"2014-12","conditions":"Varicose Vein of Lower Limbs","enrollment":50},{"nctId":"NCT00621062","phase":"NA","title":"Prospective Randomized Trial Comparing the New Endovenous Procedures Versus Conventional Surgery for Varicose Veins Due to Great Saphenous Vein Incompetence","status":"COMPLETED","sponsor":"Uppsala University","startDate":"2008-01","conditions":"Varicose Veins","enrollment":540},{"nctId":"NCT02010723","phase":"PHASE4","title":"Surgery Versus Sclerotherapy for Isolated Accessory Great Saphenous Vein Varicosis","status":"COMPLETED","sponsor":"Medical University of Vienna","startDate":"2006-06","conditions":"Varicose Veins","enrollment":40},{"nctId":"NCT00529672","phase":"PHASE3","title":"Surgery or Noninvasive Therapy for Varicose Veins","status":"UNKNOWN","sponsor":"Erasmus Medical Center","startDate":"2007-05","conditions":"Varicose Vein","enrollment":240},{"nctId":"NCT00348764","phase":"PHASE3","title":"ESGVS: Sclerotherapy With Lauromacrogol","status":"COMPLETED","sponsor":"University Hospital, Grenoble","startDate":"2004-03","conditions":"Venous Insufficiency, Saphenous Vein","enrollment":150}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":322,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"sclerotherapy with aethoxysclerol foam","genericName":"sclerotherapy with aethoxysclerol foam","companyName":"Medical University of Vienna","companyId":"medical-university-of-vienna","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Aethoxysclerol foam causes endothelial damage and thrombosis within varicose veins, leading to vessel fibrosis and obliteration. Used for Varicose veins of the lower extremities, Venous insufficiency.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}