Last reviewed 2026-04-20 · How we verify

SAMe

At a glance

Approved indications

• Sadness Relief
• Anxiousness Relief
• Mild Muscle Pain Relief
• Mild Joint Pain Relief
• Stiffness Relief
• Inflammation Relief
• Occasional Headache Relief
• Fatigue Relief

Common side effects

No common side effects on file.

Drug interactions

• MAOIs
• SSRIs
• Tricyclic antidepressants

Key clinical trials

• A Study of Targeted Radiation Therapy in People With Non-Small Cell Lung Cancer (NSCLC) (PHASE2)
• Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle (NA)
• Project Tendura: The Impact of Blood Flow Restriction Resistance Training (BFR-RT) in Patients With Achilles Tendon Rupture (ATR) Repair (NA)
• The Effects of 5G Radiation on Skin (NA)
• A Safety Assessment of Oral Letermovir in Infants With Symptomatic Congenital Cytomegalovirus (PHASE1)
• Effect of Kinesio Taping Application in Addition to Pilates Exercises on Core Muscle Thickness, Cognition and Mental Fatigue in Individuals With Non-specific Low Back Pain (NA)
• A Study of Upadacitinib in Adult Participants With Moderate-to-Severe Atopic Dermatitis and Inadequate Response to Dupilumab (PHASE3)
• NCI COVID-19 in Cancer Patients, NCCAPS Study

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• SAMe CI brief — competitive landscape report
• SAMe updates RSS · CI watch RSS
• Mclean Hospital portfolio CI