{"id":"same","rwe":[],"_fda":{"id":"3542b49b-f167-4a12-bd56-1c376c048ae3","set_id":"2a706f5a-62f5-4479-9686-5d0285fe529c","openfda":{"nui":["M0022794","N0000175951","N0000175594","M0014839","N0000192800","N0000005657","N0000175452"],"unii":["7LP2MPO46S","8L70Q75FXE","28WIH9KKYG","2URQ2N32W3","P6YC3EG204","GW89581OWR","935E97BOY8","GAN16C9B8O","XK4IUX8MNB","T42NAD2KHC","AE28F7PNPL","2679MF687A","CLF5YFS11O","394XK0IH40","1T6N4D9YV6","12H3K5QKN9","KV2JZ1BI6Z","333DO1RDJY","X66NSO3N35","U6WSN5SQ1Z"],"route":["ORAL"],"spl_id":["3542b49b-f167-4a12-bd56-1c376c048ae3"],"brand_name":["SAMe Liquescence 3036"],"spl_set_id":["2a706f5a-62f5-4479-9686-5d0285fe529c"],"package_ndc":["63083-3036-4"],"product_ndc":["63083-3036"],"generic_name":["SAME LIQUESCENCE"],"product_type":["HUMAN OTC DRUG"],"pharm_class_cs":["Vitamin B 12 [CS]","Nicotinic Acids [CS]","Vitamin B 6 [Chemical/Ingredient]","Analogs/Derivatives [Chemical/Ingredient]"],"substance_name":["ADEMETIONINE","ADENOSINE TRIPHOSPHATE","BOS TAURUS LIMBIC SYSTEM","CALCIUM LACTATE","CYANOCOBALAMIN","FERROUS CATION","FOLIC ACID","GLUTATHIONE","HYPERICUM PERFORATUM WHOLE","MAGNESIUM GLUCONATE","METHIONINE","NIACIN","PASSIFLORA INCARNATA FLOWERING TOP","PHOSPHATIDYL SERINE","PHOSPHATIDYLCHOLINE, SOYBEAN","POTASSIUM GLUCONATE","PYRIDOXINE","SEROTONIN","THIAMINE","ZINC GLUCONATE"],"pharm_class_epc":["Vitamin B12 [EPC]","Nicotinic Acid [EPC]","Vitamin B6 Analog [EPC]"],"manufacturer_name":["Professional Complementary Health Formulas"],"is_original_packager":[true]},"purpose":["*Claims based on traditional homeopathic practice, not accepted medical evidence. Not FDA evaluated."],"version":"2","warnings":["WARNINGS Consult a doctor if condition worsens or if symptoms persist. Keep out of the reach of children. In case of overdose, get medical help or contact a poison control center right away. If pregnant or breastfeeding, ask a healthcare professional before use. Keep out of the reach of children. If pregnant or breastfeeding, ask a healthcare professional before use."],"questions":["QUESTIONS Professional Formulas PO Box 2034 Lake Oswego, OR 97035"],"effective_time":"20260108","active_ingredient":["ACTIVE INGREDIENTS Passiflora incarnata 1X SAMe 3X Methionine 4X Vitamin B12 4X ATP 6X Folic acid 6X Hypericum perforatum 6X Phosphatidylcholine 6X Phosphatidylserine 6X Vitamin B3 6X Vitamin B6 6X Limbic system 8X Vitamin B1 8X Calcium lactate 9X Zinc gluconate 9X Glutathione 12X Iron gluconate 12X Serotonin 12X Magnesium gluconate 15X Potassium gluconate 15X"],"inactive_ingredient":["INACTIVE INGREDIENTS 20% ethanol, purified water."],"indications_and_usage":["INDICATIONS For the temporary relief of sadness, anxiousness, mild muscle or joint pain, stiffness, or inflammation, occasional headache, or fatigue.*"],"other_safety_information":["OTHER INFORMATION Tamper resistant. If seal is broken, do not use. After opening, close container tightly and store at room temperature away from heat."],"dosage_and_administration":["DIRECTIONS Place drops under tongue 30 minutes before/after meals. Adults and children 12 years and over: Take one full dropper up to 2 times per day. Consult a physician for use in children under 12 years of age."],"spl_product_data_elements":["SAMe Liquescence 3036 SAMe Liquescence PASSIFLORA INCARNATA FLOWERING TOP PASSIFLORA INCARNATA FLOWERING TOP ADEMETIONINE ADEMETIONINE METHIONINE METHIONINE CYANOCOBALAMIN CYANOCOBALAMIN ADENOSINE TRIPHOSPHATE ADENOSINE TRIPHOSPHATE FOLIC ACID FOLIC ACID HYPERICUM PERFORATUM WHOLE HYPERICUM PERFORATUM WHOLE PHOSPHATIDYLCHOLINE, SOYBEAN PHOSPHATIDYLCHOLINE, SOYBEAN PHOSPHATIDYL SERINE PHOSPHATIDYL SERINE NIACIN NIACIN PYRIDOXINE PYRIDOXINE BOS TAURUS LIMBIC SYSTEM BOS TAURUS LIMBIC SYSTEM THIAMINE THIAMINE ION CALCIUM LACTATE CALCIUM CATION ZINC GLUCONATE ZINC CATION GLUTATHIONE GLUTATHIONE FERROUS CATION FERROUS CATION SEROTONIN SEROTONIN MAGNESIUM GLUCONATE MAGNESIUM CATION POTASSIUM GLUCONATE POTASSIUM CATION ALCOHOL WATER"],"pregnancy_or_breast_feeding":["If pregnant or breastfeeding, ask a healthcare professional before use."],"keep_out_of_reach_of_children":["Keep out of the reach of children."],"package_label_principal_display_panel":["LABEL Est 1985 Professional Formulas Complementary Health SAMe Liquescence Homeopathic Remedy 4 FL. OZ. (118 mL) Label image"]},"tags":[],"safety":{"boxedWarnings":[],"drugInteractions":["MAOIs","SSRIs","Tricyclic antidepressants"],"commonSideEffects":[],"contraindications":[],"specialPopulations":{"elderly":"Use with caution; monitor for side effects","children":"Not recommended due to lack of safety data","lactation":"Not recommended due to lack of safety data","pregnancy":"Not recommended due to lack of safety data"}},"trials":[],"_chembl":{"chemblId":"CHEMBL5776358","moleculeType":null,"molecularWeight":"474.40"},"aliases":["S-adenosyl-L-methionine"],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=SAMe","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:55:41.002350+00:00"},"timeline":{"url":"https://en.wikipedia.org/wiki/Same","method":"deterministic","source":"Wikipedia","rawText":"","confidence":0.8,"sourceType":"wikipedia","retrievedAt":"2026-04-20T00:55:47.649978+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:55:46.056699+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=SAMe","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:55:46.578822+00:00"},"mechanism.drugClass":{"url":"https://api.fda.gov/drug/label.json","method":"deterministic","source":"FDA Label (EPC)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:55:39.744786+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:55:39.744826+00:00"},"indications.approved":{"url":"","method":"ai_extraction","source":"FDA Label + AI","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:56:13.921039+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (no boxed warning)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:55:39.744837+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL5776358/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:55:47.280844+00:00"}},"offLabel":[],"timeline":[],"_dailymed":{"setId":"2a706f5a-62f5-4479-9686-5d0285fe529c","title":"SAME LIQUESCENCE 3036 (SAME LIQUESCENCE) LIQUID [PROFESSIONAL COMPLEMENTARY HEALTH FORMULAS]"},"ecosystem":[],"mechanism":{"target":"Methyltransferases","novelty":"SAMe is a naturally occurring compound with a unique mechanism of action that differentiates it from traditional pharmaceuticals.","modality":"Oral supplementation","drugClass":"Vitamin B12 [EPC]","explanation":"","oneSentence":"","technicalDetail":"SAMe is synthesized from methionine and adenosine triphosphate (ATP) in a reaction catalyzed by the enzyme methionine adenosyltransferase. It then donates its methyl group to various substrates, including DNA, proteins, and lipids, through the action of methyltransferases."},"_scrapedAt":"2026-03-28T04:23:51.990Z","_scrapedBy":"cloudflare-swarm","_wikipedia":{"url":"https://en.wikipedia.org/wiki/S-Adenosyl_methionine","title":"S-Adenosyl methionine","extract":"S-Adenosyl methionine (SAM), also known under the commercial names of SAMe, SAM-e, or AdoMet, is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. Although these anabolic reactions occur throughout the body, most SAM is produced and consumed in the liver. More than 40 methyl transfers from SAM are known, to various substrates such as nucleic acids, proteins, lipids and secondary metabolites. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase. SAM was first discovered by Giulio Cantoni in 1952."},"commercial":{"yoyGrowth":"N/A","launchDate":"N/A","annualCostUS":"N/A","currentRevenue":"N/A","patientPopulation":"N/A","peakSalesEstimate":"N/A"},"references":[],"_validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T00:56:14.045836+00:00","fieldsConflicting":2,"overallConfidence":0.8},"biosimilars":[],"competitors":[],"indications":{"approved":[{"id":"same-sadness-relief","name":"Sadness Relief","dosing":null,"approvals":[],"diseaseId":"","eligibility":"General population","pivotalTrial":null,"restrictions":[],"patientPopulation":"General population","diagnosticRequired":null,"brandNameForIndication":""},{"id":"same-anxiousness-relief","name":"Anxiousness Relief","dosing":null,"approvals":[],"diseaseId":"","eligibility":"General population","pivotalTrial":null,"restrictions":[],"patientPopulation":"General population","diagnosticRequired":null,"brandNameForIndication":""},{"id":"same-mild-muscle-pain-relief","name":"Mild Muscle Pain Relief","dosing":null,"approvals":[],"diseaseId":"","eligibility":"General population","pivotalTrial":null,"restrictions":[],"patientPopulation":"General population","diagnosticRequired":null,"brandNameForIndication":""},{"id":"same-mild-joint-pain-relief","name":"Mild Joint Pain Relief","dosing":null,"approvals":[],"diseaseId":"","eligibility":"General population","pivotalTrial":null,"restrictions":[],"patientPopulation":"General population","diagnosticRequired":null,"brandNameForIndication":""},{"id":"same-stiffness-relief","name":"Stiffness Relief","dosing":null,"approvals":[],"diseaseId":"","eligibility":"General population","pivotalTrial":null,"restrictions":[],"patientPopulation":"General population","diagnosticRequired":null,"brandNameForIndication":""},{"id":"same-inflammation-relief","name":"Inflammation Relief","dosing":null,"approvals":[],"diseaseId":"","eligibility":"General population","pivotalTrial":null,"restrictions":[],"patientPopulation":"General population","diagnosticRequired":null,"brandNameForIndication":""},{"id":"same-occasional-headache-relief","name":"Occasional Headache Relief","dosing":null,"approvals":[],"diseaseId":"","eligibility":"General population","pivotalTrial":null,"restrictions":[],"patientPopulation":"General population","diagnosticRequired":null,"brandNameForIndication":""},{"id":"same-fatigue-relief","name":"Fatigue Relief","dosing":null,"approvals":[],"diseaseId":"","eligibility":"General population","pivotalTrial":null,"restrictions":[],"patientPopulation":"General population","diagnosticRequired":null,"brandNameForIndication":""}],"offLabel":["temporary relief of sadness","anxiousness","mild muscle or joint pain","stiffness","inflammation","occasional headache","fatigue"],"pipeline":[]},"labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT05657873","phase":"PHASE2","title":"A Study of Targeted Radiation Therapy in People With Non-Small Cell Lung Cancer (NSCLC)","status":"RECRUITING","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"2022-12-09","conditions":"Non Small Cell Lung Cancer, Non Small Cell Lung Cancer Metastatic, Non-small Cell Carcinoma","enrollment":68},{"nctId":"NCT01266577","phase":"NA","title":"Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle","status":"RECRUITING","sponsor":"National Institute of Mental Health (NIMH)","startDate":"2011-01-27","conditions":"Brain Mapping, Healthy Volunteer","enrollment":300},{"nctId":"NCT07498166","phase":"NA","title":"Project Tendura: The Impact of Blood Flow Restriction Resistance Training (BFR-RT) in Patients With Achilles Tendon Rupture (ATR) Repair","status":"ACTIVE_NOT_RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2026-02-01","conditions":"Achilles Tendon Rupture, Blood Flow Restriction Therapy, Achilles Tendon Repairs/Reconstructions","enrollment":75},{"nctId":"NCT05933954","phase":"NA","title":"The Effects of 5G Radiation on Skin","status":"RECRUITING","sponsor":"Prof. Olivier Gaide, MD-PhD","startDate":"2024-01-09","conditions":"Electromagnetic Radiation (5GFR2)","enrollment":42},{"nctId":"NCT06118515","phase":"PHASE1","title":"A Safety Assessment of Oral Letermovir in Infants With Symptomatic Congenital Cytomegalovirus","status":"RECRUITING","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2025-02-19","conditions":"Congenital Cytomegalovirus Infection","enrollment":12},{"nctId":"NCT06787079","phase":"NA","title":"Effect of Kinesio Taping Application in Addition to Pilates Exercises on Core Muscle Thickness, Cognition and Mental Fatigue in Individuals With Non-specific Low Back Pain","status":"COMPLETED","sponsor":"Istanbul Saglik Bilimleri University","startDate":"2025-05-01","conditions":"Low Back Pain, Non Specific Low Back Pain","enrollment":54},{"nctId":"NCT06389136","phase":"PHASE3","title":"A Study of Upadacitinib in Adult Participants With Moderate-to-Severe Atopic Dermatitis and Inadequate Response to Dupilumab","status":"RECRUITING","sponsor":"AbbVie","startDate":"2024-06-14","conditions":"Atopic Dermatitis","enrollment":200},{"nctId":"NCT04387656","phase":"","title":"NCI COVID-19 in Cancer Patients, NCCAPS Study","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2020-06-05","conditions":"COVID-19 Infection, Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm","enrollment":1877},{"nctId":"NCT03559283","phase":"NA","title":"fNIRS in the Evaluation of Cognitive-motor Interference in Post-stroke Patients","status":"COMPLETED","sponsor":"University Hospital, Limoges","startDate":"2018-11-26","conditions":"D020521","enrollment":11},{"nctId":"NCT04040634","phase":"NA","title":"Optimal Blood Pressure for the prevenTIon of Major vAscuLar Events in Patients With DIABETES Mellitus (OPTIMAL-DIABETES)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Hospital Israelita Albert Einstein","startDate":"2019-08-08","conditions":"Diabetes Mellitus, High Blood Pressure, Cardiovascular Diseases","enrollment":9476},{"nctId":"NCT07020065","phase":"PHASE2","title":"Reduced-dose Carboplatin-doublet-chemotherapy + Cemiplimab vs Cemiplimab Monotherapy in Treatment Naive Older and Frail Patients With Metastatic NSCLC With PD-L1 <50%","status":"NOT_YET_RECRUITING","sponsor":"Swiss Cancer Institute","startDate":"2026-05","conditions":"Metastatic NSCLC - Non-Small Cell Lung Cancer","enrollment":156},{"nctId":"NCT07253532","phase":"NA","title":"Vibrotactile Balance Belt Effect on Improving Gait","status":"RECRUITING","sponsor":"Johns Hopkins University","startDate":"2026-03-20","conditions":"Vestibular Hypofunction, Ataxia - Other, Gait Impairment","enrollment":90},{"nctId":"NCT05241041","phase":"NA","title":"Effects of Positive Psychological Group Psychotherapy and Auricular Acupressure on Withdrawal Symptoms","status":"COMPLETED","sponsor":"Inha University Hospital","startDate":"2021-09-13","conditions":"Gambling","enrollment":198},{"nctId":"NCT07495475","phase":"NA","title":"Mobile App-Supported Exercise Program For Mechanical Low Back Pain","status":"NOT_YET_RECRUITING","sponsor":"Karabuk University","startDate":"2026-04-01","conditions":"Mechanical Low Back Pain","enrollment":50},{"nctId":"NCT07105943","phase":"NA","title":"Manipulating Exercise Intensity and Affective Responses for Cardiac Rehabilitation Program Acute Coronary Syndrome Patients","status":"NOT_YET_RECRUITING","sponsor":"Instituto Politécnico de Leiria","startDate":"2026-03-01","conditions":"Affect and Exertion During and Post-exercise","enrollment":52},{"nctId":"NCT07170033","phase":"NA","title":"The Effect of the DASH Diet on Treatment Outcomes in Adults Diagnosed With Rheumatoid Arthritis","status":"COMPLETED","sponsor":"Istanbul Health and Technology University","startDate":"2024-05-06","conditions":"Rheumatoid Arthritis","enrollment":49},{"nctId":"NCT07498660","phase":"NA","title":"PRP Injection Into the Sacroiliac Joint After Ipsilateral THA: Effects on Early Recovery and Function (SIJ-THA Randomized Trial)","status":"NOT_YET_RECRUITING","sponsor":"Medical University of Warsaw","startDate":"2026-04-01","conditions":"Osteoarthitis, Sacro Iliac Joint Pain, Hip Arthroplasty, Total","enrollment":60},{"nctId":"NCT06898606","phase":"PHASE1, PHASE2","title":"Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory Depression","status":"RECRUITING","sponsor":"Federal University of Latin American Integration","startDate":"2024-09-05","conditions":"Depressive Disorder","enrollment":24},{"nctId":"NCT07030166","phase":"","title":"A Machine Learning Prediction Model for Postoperative Acute Kidney Injury in Non-Cardiac Surgery Patients","status":"RECRUITING","sponsor":"Lanyue Zhu","startDate":"2025-07-01","conditions":"Kidney Injury, Acute","enrollment":10000},{"nctId":"NCT03741023","phase":"NA","title":"Disorders of the Acute Phase Response Following Trauma and Invasive Surgery","status":"ENROLLING_BY_INVITATION","sponsor":"Vanderbilt University Medical Center","startDate":"2019-12-12","conditions":"Acute Phase Response","enrollment":320},{"nctId":"NCT06964529","phase":"NA","title":"Evaluation of the Effects of I-PRF and C-PRF on Gingival Phenotype","status":"COMPLETED","sponsor":"Inonu University","startDate":"2025-02-11","conditions":"Thin Gingival Biotype, Thin Gingiva","enrollment":30},{"nctId":"NCT06023537","phase":"NA","title":"Using Technology to Investigate Lapses in a Weight Loss Program Among Individuals With Overweight and Obesity","status":"COMPLETED","sponsor":"Williams College","startDate":"2023-07-11","conditions":"Obesity, Weight Loss","enrollment":119},{"nctId":"NCT03620019","phase":"PHASE2","title":"Denosumab + PD-1 in Subjects With Stage III/ IV Melanoma","status":"COMPLETED","sponsor":"UNC Lineberger Comprehensive Cancer Center","startDate":"2018-09-10","conditions":"Melanoma Stage Iii, Melanoma Stage Iv, Melanoma","enrollment":25},{"nctId":"NCT03574909","phase":"PHASE3","title":"IRELAnD: Investigating the Role of Early Low-dose Aspirin in Diabetes","status":"COMPLETED","sponsor":"Royal College of Surgeons, Ireland","startDate":"2018-09-01","conditions":"Pre-Gestational Diabetes","enrollment":137},{"nctId":"NCT00109174","phase":"NA","title":"MRS Measurement of Glutamate and GABA Metabolism in Brain","status":"RECRUITING","sponsor":"National Institute of Mental Health (NIMH)","startDate":"2006-09-06","conditions":"Normal Physiology","enrollment":200},{"nctId":"NCT02834013","phase":"PHASE2","title":"Nivolumab and Ipilimumab in Treating Patients With Rare Tumors","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2017-01-30","conditions":"Acinar Cell Carcinoma, Adenoid Cystic Carcinoma, Adrenal Cortical Carcinoma","enrollment":818},{"nctId":"NCT04411147","phase":"","title":"A Longitudinal Study of COVID-19 Sequelae and Immunity","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2020-06-17","conditions":"COVID-19","enrollment":583},{"nctId":"NCT06686485","phase":"","title":"cOncomitant Left Atrial aPpendage Closure and Pulsed Field ablaTION-Asia","status":"RECRUITING","sponsor":"Boston Scientific Corporation","startDate":"2025-03-18","conditions":"Concomitant Procedures, Atrial Fibrillation, PFA","enrollment":433},{"nctId":"NCT07495878","phase":"NA","title":"Educational Cartoon to Reduce Preoperative Anxiety in Children (CALM-KIDS)","status":"RECRUITING","sponsor":"Mehmet Burak Eşkin","startDate":"2026-01-01","conditions":"Pediatric Preoperative Anxiety, Children, Educational Cartoon","enrollment":159},{"nctId":"NCT02728635","phase":"NA","title":"Epigenetic Regulation of Human Adipose Tissue Distribution","status":"ACTIVE_NOT_RECRUITING","sponsor":"AdventHealth Translational Research Institute","startDate":"2016-07","conditions":"Obesity","enrollment":27},{"nctId":"NCT04019002","phase":"PHASE1","title":"Hyperpolarized Carbon-13 (13C) Pyruvate Imaging in Patients With Glioblastoma","status":"COMPLETED","sponsor":"Susan Chang","startDate":"2019-11-19","conditions":"Glioblastoma Multiforme (GBM)","enrollment":17},{"nctId":"NCT07495254","phase":"NA","title":"Effectiveness of Combined Super Inductive System (SIS) Therapy With Therapeutic Exercise and Health Education in Lateral Elbow Tendinopathy","status":"NOT_YET_RECRUITING","sponsor":"University of Vic - Central University of Catalonia","startDate":"2026-03-30","conditions":"Lateral Epicondylitis (Tennis Elbow), Lateral Epicondylalgia, Lateral Elbow Tendinopathy","enrollment":224},{"nctId":"NCT04216394","phase":"","title":"Anticoagulation in Emergency General Surgery","status":"COMPLETED","sponsor":"Methodist Health System","startDate":"2019-10-31","conditions":"Emergency General Surgery","enrollment":4},{"nctId":"NCT07495150","phase":"NA","title":"Intracalvariosseous Plus Intravenous Antibiotics for Moderate-to-Severe Bacterial Meningitis","status":"NOT_YET_RECRUITING","sponsor":"yilong Wang","startDate":"2026-04-01","conditions":"Blood-Brain Barrier, Bacterial Meningitis","enrollment":86},{"nctId":"NCT07113691","phase":"PHASE1","title":"Iadademstat + SBRT With Atezo in ES-SCLC","status":"RECRUITING","sponsor":"Yale University","startDate":"2026-01-20","conditions":"Extensive Stage Small Cell Lung Cancer (ES-SCLC)","enrollment":15},{"nctId":"NCT02311374","phase":"EARLY_PHASE1","title":"Human Brain Mapping of the Apparent Diffusion Coefficient (ADC) During Sleep and Wakefulness","status":"COMPLETED","sponsor":"National Institute on Alcohol Abuse and Alcoholism (NIAAA)","startDate":"2015-07-28","conditions":"Brain Mapping","enrollment":40},{"nctId":"NCT07498153","phase":"NA","title":"Spotting Syphilis: A Dual Point-of-Care Syphilis Screening Initiative in a Low-Resource Healthcare Setting","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2025-09-30","conditions":"Syphilis, HIV Infections","enrollment":149},{"nctId":"NCT07494071","phase":"NA","title":"Improving Family Communication in Older Adults: A Pilot Randomized Controlled Trial","status":"NOT_YET_RECRUITING","sponsor":"The University of Hong Kong","startDate":"2026-04","conditions":"Intergenerational Relations","enrollment":40},{"nctId":"NCT07422766","phase":"","title":"Comparison of Non-Invasive Mean Arterial Blood Pressure Measurements at the Arm and Ankle During Elective Cesarean Delivery.","status":"RECRUITING","sponsor":"St. Justine's Hospital","startDate":"2026-02-26","conditions":"Pregnancy, Cesarean Delivery, Blood Pressure Measurement in Pregnancy","enrollment":110},{"nctId":"NCT06665074","phase":"PHASE2","title":"Inflammatory Challenge in Human Aggression.","status":"RECRUITING","sponsor":"Ohio State University","startDate":"2026-02-16","conditions":"Intermittent Explosive Disorder","enrollment":112},{"nctId":"NCT05158166","phase":"PHASE1, PHASE2","title":"DaxibotulinumtoxinA Injection for Treatment of Adductor Spasmodic Dysphonia","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2023-10-13","conditions":"Adductor Spasmodic Dysphonia, Voice Disorders, Spasmodic Dysphonia","enrollment":22},{"nctId":"NCT06545214","phase":"NA","title":"Caracterization of the Combined Alterations in Respiration and aROUSal in Patients With Drug-resistant EpiLepsy","status":"RECRUITING","sponsor":"Hospices Civils de Lyon","startDate":"2024-11-04","conditions":"Epilepsy","enrollment":60},{"nctId":"NCT00055055","phase":"","title":"Study of Families With Twins or Siblings Discordant for Rheumatic Disorders","status":"COMPLETED","sponsor":"National Institute of Environmental Health Sciences (NIEHS)","startDate":"2003-04-21","conditions":"Rheumatoid Arthritis, Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathies","enrollment":1056},{"nctId":"NCT04503694","phase":"PHASE2","title":"Neoadjuvant Regorafenib in Combination With Nivolumab and Short-course Radiotherapy in Stage II-III Rectal Cancer","status":"ACTIVE_NOT_RECRUITING","sponsor":"Jules Bordet Institute","startDate":"2021-03-25","conditions":"Rectal Cancer Stage II, Rectal Cancer Stage III","enrollment":72},{"nctId":"NCT03354741","phase":"NA","title":"Stimulation of Acupuncture Points by Athermic Laser Therapy for the Prevention of Chemotherapy Induced Nausea and Vomiting in Children","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire de Nice","startDate":"2019-05-23","conditions":"Children, Chemotherapy-induced Nausea and Vomiting, Malignant Tumor","enrollment":30},{"nctId":"NCT06544187","phase":"","title":"Can Imaging be an Alternative to Exercise Testing as a Predictor of Surgical Fitness?","status":"RECRUITING","sponsor":"University Hospitals of North Midlands NHS Trust","startDate":"2025-01-06","conditions":"Surgical Fitness, Imaging","enrollment":56},{"nctId":"NCT07496398","phase":"","title":"Median and Ulnar Nerve Function in Tattoo Artists","status":"RECRUITING","sponsor":"Gazi University","startDate":"2026-03-01","conditions":"Peripheral Neuropathy Pain, Carpal Tunnel Syndrome (CTS), Cubital Tunnel Syndrome","enrollment":20},{"nctId":"NCT07497568","phase":"NA","title":"Effect of Local Application of 1% Metformin Gel on Implant Stability and Peri-implant Bone Density: A Randomized Controlled Study","status":"RECRUITING","sponsor":"University of Baghdad","startDate":"2025-11-01","conditions":"Dental Implant, Stability","enrollment":34},{"nctId":"NCT07316985","phase":"","title":"Efficacy of Physical Fitness Training Combined With Exercise Therapy on Gait in Children With Cerebral Palsy","status":"COMPLETED","sponsor":"LiNa Zhang","startDate":"2023-06-01","conditions":"Spastic Cerebral Palsy","enrollment":72},{"nctId":"NCT07003425","phase":"PHASE2","title":"A Long-term Safety and Efficacy Study Evaluating APG777 in Atopic Dermatitis","status":"RECRUITING","sponsor":"Apogee Therapeutics, Inc.","startDate":"2025-05-14","conditions":"Atopic Dermatitis","enrollment":350},{"nctId":"NCT07482501","phase":"NA","title":"Repetitive Transcranial Magnetic Stimulation in Cardiac Autonomic Dysfunction","status":"RECRUITING","sponsor":"Afyonkarahisar Health Sciences University","startDate":"2026-03-26","conditions":"Stroke, Autonomic Dysfunction, Hemiparesis","enrollment":44},{"nctId":"NCT07497646","phase":"NA","title":"Repeated Bilateral Greater Occipital Nerve Blockade in Chronic Migraine and Chronic Tension-Type Headache","status":"COMPLETED","sponsor":"Saglik Bilimleri Universitesi","startDate":"2025-01-01","conditions":"Chronic Migraine Headache, Chronic Tension-type Headache","enrollment":290},{"nctId":"NCT01829724","phase":"","title":"Cerebral Palsy and the Study of Brain Activity During Motor Tasks","status":"RECRUITING","sponsor":"National Institutes of Health Clinical Center (CC)","startDate":"2013-08-22","conditions":"Cerebral Palsy, Children","enrollment":320},{"nctId":"NCT04314401","phase":"","title":"National Cancer Institute \"Cancer Moonshot Biobank\"","status":"RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2020-11-11","conditions":"Acute Myeloid Leukemia, Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8","enrollment":1600},{"nctId":"NCT05880095","phase":"NA","title":"Healthy Aging Through Time- Restricted Eating in Adults With Overweight/Obesity and Incipient Liver Disease: ENSATI","status":"COMPLETED","sponsor":"IMDEA Food","startDate":"2023-07-05","conditions":"Biological Aging","enrollment":176},{"nctId":"NCT07495137","phase":"NA","title":"The Improvement Effect of Real-time Artificial Intelligence Assisted Identification of Bleeding Points on Hemostasis Efficiency in Endoscopic Submucosal Dissection","status":"NOT_YET_RECRUITING","sponsor":"Qilu Hospital of Shandong University","startDate":"2026-03-31","conditions":"Endoscopic Submucosal Dissection, Endoscopic Submucosal Dissection (ESD)","enrollment":160},{"nctId":"NCT07289347","phase":"NA","title":"EFFECT OF A LIGHT STIMULATED FOOTSTEPS PATHWAY ON GAIT IN SPASTIC CHILDREN","status":"ACTIVE_NOT_RECRUITING","sponsor":"Amira saad mohamed","startDate":"2025-09-20","conditions":"Spastic Diplegia","enrollment":30},{"nctId":"NCT07169630","phase":"PHASE1","title":"PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)","status":"RECRUITING","sponsor":"National Institute of Mental Health (NIMH)","startDate":"2026-04-01","conditions":"Alzheimer s Disease, Mild Cognitive Impairment, Healthy","enrollment":90},{"nctId":"NCT07496944","phase":"NA","title":"Effects of Blood Flow Restriction and Small-Sided Games on Soccer Passing and Dribbling Stability Under Fatigue","status":"COMPLETED","sponsor":"Beijing Sport University","startDate":"2026-01-20","conditions":"Athletic Performance","enrollment":40},{"nctId":"NCT07495332","phase":"NA","title":"Siemens Biomarker Multi-modality","status":"RECRUITING","sponsor":"Duke University","startDate":"2026-03","conditions":"Fatty Liver, Hepatic Steatosis","enrollment":45},{"nctId":"NCT07217366","phase":"NA","title":"Speech-to-text Tool for Heart Failure Patient-Reported Data","status":"ENROLLING_BY_INVITATION","sponsor":"Stanford University","startDate":"2025-10-13","conditions":"Heart Failure","enrollment":100},{"nctId":"NCT07339202","phase":"NA","title":"Preoperative Hemodialysis Timing in Patients With End-Stage Kidney Disease: The POD-ESKD Pilot Trial","status":"NOT_YET_RECRUITING","sponsor":"Stanford University","startDate":"2026-04-16","conditions":"Perioperative Management, End Stage Kidney Disease (ESRD), Hemodialysis","enrollment":30},{"nctId":"NCT03783000","phase":"PHASE1","title":"A Study in Healthy Men to Measure the Amount of BI 425809 in the Blood When Taken as a Tablet","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2019-01-15","conditions":"Healthy","enrollment":6},{"nctId":"NCT07497464","phase":"","title":"Validity of an Open-access Handedness Recognition Task in Stroke Patients","status":"RECRUITING","sponsor":"Alfredo Lerín Calvo","startDate":"2025-10-07","conditions":"Stroke","enrollment":30},{"nctId":"NCT07495085","phase":"NA","title":"Manual Therapy in Improving Quality of Life in Women With Dyspareunia","status":"COMPLETED","sponsor":"University of Trás-os-Montes and Alto Douro","startDate":"2025-02-01","conditions":"Female, Dyspareunia","enrollment":50},{"nctId":"NCT07486037","phase":"NA","title":"Caring for Caregivers","status":"RECRUITING","sponsor":"Indiana University","startDate":"2026-03-01","conditions":"Intervention Group, Treatment as Usual","enrollment":25},{"nctId":"NCT07244991","phase":"NA","title":"Effect of MI Paste Plus™ on Streptococcus Mutans and White Spot Lesions in Fixed Orthodontics","status":"RECRUITING","sponsor":"Cardenal Herrera University","startDate":"2026-01-04","conditions":"Dental Caries, Streptococcus Mutans, Tooth Demineralization","enrollment":200},{"nctId":"NCT06036316","phase":"NA","title":"Study of Language Disorders and Interactions Between Mnesic Capabilities and Semantic Competencies in Patients With Psychosis","status":"RECRUITING","sponsor":"Centre Psychothérapique de Nancy","startDate":"2024-01-23","conditions":"Psychosis, Schizophrenia, At-risk Mental State","enrollment":90},{"nctId":"NCT07394738","phase":"NA","title":"Using Different Biomaterials to Preserve Bone After Tooth Extraction","status":"ACTIVE_NOT_RECRUITING","sponsor":"Inonu University","startDate":"2025-04-09","conditions":"Alveolar Ridge Preservation, Bone Regeneration, Tooth Extraction","enrollment":40},{"nctId":"NCT05353049","phase":"NA","title":"How to Bathe a Person With Dementia? A Bathing Intervention Based on Basale Stimulation® for People With Moderate to Severe Dementia","status":"COMPLETED","sponsor":"University of Salamanca","startDate":"2021-11-01","conditions":"Patient Engagement, Behavioral Symptoms","enrollment":50},{"nctId":"NCT05165810","phase":"NA","title":"Evaluation of Multiple Interventions to Improve HIV Treatment Outcomes Among People Who Inject Drugs in India","status":"ACTIVE_NOT_RECRUITING","sponsor":"Johns Hopkins University","startDate":"2023-03-09","conditions":"HIV Infections","enrollment":800},{"nctId":"NCT05470010","phase":"NA","title":"Smartphone App-Based Mindfulness Intervention for French and English Speaker Cancer Survivors","status":"RECRUITING","sponsor":"Canadian Cancer Trials Group","startDate":"2025-03-07","conditions":"Cancer, Psychological","enrollment":345},{"nctId":"NCT07410000","phase":"NA","title":"Ultrasound-Guided Quadro-Iliac Plane Block for Pain Management After Total Hip Arthroplasty","status":"RECRUITING","sponsor":"Bursa City Hospital","startDate":"2026-03-16","conditions":"Pain Management, Total Hip Arthroplasty","enrollment":100},{"nctId":"NCT07497659","phase":"NA","title":"Ischemic Preconditioning in Resistance Exercise in Older Women","status":"COMPLETED","sponsor":"Universidade Federal do Triangulo Mineiro","startDate":"2025-05-28","conditions":"Blood Pressure, Hemodynamic Response, Rating of Perceived Exertion","enrollment":30},{"nctId":"NCT07296094","phase":"PHASE2","title":"Psilocybin-Assisted Psychotherapy for the Treatment of Severe Alcohol Use Disorder","status":"NOT_YET_RECRUITING","sponsor":"Brigham and Women's Hospital","startDate":"2026-05-01","conditions":"Alcohol Use Disorder","enrollment":36},{"nctId":"NCT06623617","phase":"NA","title":"The Impact of Breathing Training on PPSUI: A Randomized Controlled Trial","status":"RECRUITING","sponsor":"Jie Li","startDate":"2025-05-01","conditions":"Stress Urinary Incontinence (SUI)","enrollment":58},{"nctId":"NCT07498530","phase":"NA","title":"Virtual Assistant for Exercise Adherence in Older ADULTS","status":"RECRUITING","sponsor":"University of Valencia","startDate":"2026-02-01","conditions":"Older Adult, Exercise, Adherence","enrollment":70},{"nctId":"NCT06692335","phase":"NA","title":"HIFU Versus Myomectomy for the Treatment of Symptomatic Uterine Fibroids","status":"RECRUITING","sponsor":"Chinese University of Hong Kong","startDate":"2025-02-06","conditions":"Uterine Fibroids (UF)","enrollment":112},{"nctId":"NCT06689878","phase":"NA","title":"Mobile Cognitive Behavioral Therapy for Stroke","status":"RECRUITING","sponsor":"Weill Medical College of Cornell University","startDate":"2025-02-25","conditions":"Anxiety, Stroke, Depression","enrollment":10},{"nctId":"NCT07498816","phase":"NA","title":"Impact of Immersive Virtual Reality (IVR) on Respiratory Effort: A Pilot Study in Healthy Adults","status":"RECRUITING","sponsor":"Pontificia Universidad Catolica de Chile","startDate":"2025-10-01","conditions":"Virtual Reality, Respiratory Effort, Exercise","enrollment":10},{"nctId":"NCT06114264","phase":"NA","title":"Multimodal Intervention in Patients With Non-specific Chronic Low Back Pain: the HEALTHY BACK Project","status":"COMPLETED","sponsor":"IBS Granada","startDate":"2023-01-01","conditions":"Pain, Chronic, Neurologic Manifestations, Back Pain","enrollment":70},{"nctId":"NCT05531786","phase":"PHASE1, PHASE2","title":"Phase I/II Study of Pacritinib, A JAK2/IRAK1/CSF1R Inhibitor, in Refractory Chronic Graft-Versus-Host Disease (cGVHD) After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)","status":"RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2023-03-06","conditions":"Graft vs Host Disease","enrollment":50},{"nctId":"NCT07494448","phase":"PHASE1, PHASE2","title":"Phase Ib/II Study of Zanidatamab Plus Tucatinib and Chemotherapy in HER2-Positive Advanced Breast Cancer","status":"NOT_YET_RECRUITING","sponsor":"MedSIR","startDate":"2026-07-01","conditions":"HER 2 Positive Advanced Breast Cancer, Breast Cancer","enrollment":24},{"nctId":"NCT07498777","phase":"NA","title":"Individual Alpha Frequency-Based rTMS for Post-Stroke Motor Recovery: Efficacy and Neurophysiological Mechanisms","status":"NOT_YET_RECRUITING","sponsor":"National Taiwan University Hospital","startDate":"2026-04-01","conditions":"Ischemic Stroke","enrollment":34},{"nctId":"NCT07398898","phase":"NA","title":"Use of Augmented Reality Glasses and Noise-Cancelling Headphones to Reduce Dental Anxiety in Adult Patients","status":"RECRUITING","sponsor":"Medical University of Warsaw","startDate":"2026-03-01","conditions":"Dental Anxiety, Music Therapy, Oral Surgical Procedures","enrollment":250},{"nctId":"NCT01143558","phase":"EARLY_PHASE1","title":"Searching for Persistence of Infection in Lyme Disease","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2010-11-04","conditions":"Lyme Disease","enrollment":45},{"nctId":"NCT07141888","phase":"NA","title":"The Effects of a Probiotic Food Supplement in Hyperuricaemia","status":"RECRUITING","sponsor":"Örebro University, Sweden","startDate":"2025-12-16","conditions":"Hyperuricemia With or Without Gout","enrollment":99},{"nctId":"NCT07495995","phase":"PHASE2","title":"Single-Center Phase II Double-Blind Trial of SAMe to Prevent Liver Cancer in MASLD-Related Cirrhosis","status":"NOT_YET_RECRUITING","sponsor":"Cedars-Sinai Medical Center","startDate":"2026-04-15","conditions":"Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)","enrollment":94},{"nctId":"NCT07277660","phase":"PHASE2","title":"A Dose-ranging Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Galvokimig in Adult Study Participants With Atopic Dermatitis","status":"RECRUITING","sponsor":"UCB Biopharma SRL","startDate":"2025-12-29","conditions":"Atopic Dermatitis","enrollment":160},{"nctId":"NCT07494032","phase":"NA","title":"Extended Oral Tranexamic Acid After Primary Total Knee Arthroplasty","status":"NOT_YET_RECRUITING","sponsor":"NYU Langone Health","startDate":"2026-05-01","conditions":"Knee Arthropathy","enrollment":350},{"nctId":"NCT07361874","phase":"NA","title":"IMPACT-MACS: Adrenalectomy vs Semaglutide for Metabolic Outcomes in Mild Autonomous Cortisol Secretion","status":"RECRUITING","sponsor":"University of Texas Southwestern Medical Center","startDate":"2026-03-05","conditions":"Mild Autonomous Cortisol Secretion (MACS), Autonomous Cortisol Secretion (ACS), Subclinical Cushing's","enrollment":75},{"nctId":"NCT05210374","phase":"PHASE1","title":"Disulfiram With Copper Gluconate and Liposomal Doxorubicin in Treatment-Refractory Sarcomas","status":"RECRUITING","sponsor":"Case Comprehensive Cancer Center","startDate":"2023-03-09","conditions":"Relapsed Sarcomas","enrollment":24},{"nctId":"NCT07497997","phase":"NA","title":"PainTrain-AI Pilot: Feasibility, Usability (SUS) and Concept-Shift in Primary Care and a Specialized Setting","status":"NOT_YET_RECRUITING","sponsor":"Francesc Valenzuela Pascual","startDate":"2027-01","conditions":"Professional Training in Chronic Musculoskeletal Pain","enrollment":40},{"nctId":"NCT04127994","phase":"NA","title":"Glycemic Variability Comparing Two vs Five Meals in Type 2 Diabetes","status":"COMPLETED","sponsor":"Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran","startDate":"2018-08-17","conditions":"Diabetes Mellitus Type 2, Overweight and Obesity, Meal Time","enrollment":50},{"nctId":"NCT07496580","phase":"NA","title":"Efficacy Evaluation of Electroacupuncture in the Treatment of Functional Dyspepsia","status":"NOT_YET_RECRUITING","sponsor":"The Third Affiliated hospital of Zhejiang Chinese Medical University","startDate":"2026-03-01","conditions":"Functional Dyspepsia, Electroacupuncture","enrollment":105},{"nctId":"NCT04466488","phase":"NA","title":"Prevent TB: Choice Architecture for TPT Delivery","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2021-09-15","conditions":"HIV/AIDS, Tuberculosis","enrollment":50798},{"nctId":"NCT06418724","phase":"PHASE2","title":"Neoadjuvant PD-1 Inhibitor and EGFR Inhibitor in Locally Advanced Cutaneous Squamous Cell Carcinoma","status":"NOT_YET_RECRUITING","sponsor":"Melanoma and Skin Cancer Trials Limited","startDate":"2026-07-30","conditions":"Locally Advanced Cutaneous Squamous Cell Carcinoma","enrollment":27},{"nctId":"NCT07497815","phase":"","title":"Artificial Intelligence-assisted Diagnosis in Ophthalmology","status":"NOT_YET_RECRUITING","sponsor":"Marisse Masis-Solano","startDate":"2026-05-01","conditions":"Macular Degeneration, Diabetic Retinopathy (DR), Glaucoma","enrollment":15000},{"nctId":"NCT07498881","phase":"NA","title":"LasaiON is an Evidence-informed, Multimodal Self-regulation Program Designed to Reduce Emotional Distress and Strengthen Stress-regulation Skills by Combining Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) With Breathing Supported by Heart-rate Variability Biofeedback (HRV-B; emWave).","status":"NOT_YET_RECRUITING","sponsor":"University of the Basque Country (UPV/EHU)","startDate":"2026-03-30","conditions":"Adult","enrollment":200},{"nctId":"NCT07458100","phase":"NA","title":"The STEP-MIED Trial: Digital Stepped-Care for Emotional Disorders","status":"RECRUITING","sponsor":"Peking University","startDate":"2026-03","conditions":"Emotional Disorders, Depressive Disorder, Anxiety Disorders","enrollment":464}],"_emaApprovals":[],"_faersSignals":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{"route":"Oral"},"crossReferences":{"chemblId":"CHEMBL5776358"},"formularyStatus":[],"_approvalHistory":[],"developmentCodes":[],"ownershipHistory":[],"publicationCount":1650646,"therapeuticAreas":["Metabolic"],"biosimilarFilings":[],"companionDiagnostics":[],"genericManufacturerList":[],"phase":"marketed","status":"active","brandName":"SAMe","genericName":"SAMe","companyName":"Mclean Hospital","companyId":"mclean-hospital","modality":"Small molecule","firstApprovalDate":"N/A","aiSummary":"","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":7,"withResults":2},"validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T00:56:14.045836+00:00","fieldsConflicting":2,"overallConfidence":0.8},"verificationStatus":"partial","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":true,"score":2}}