Last reviewed · How we verify
Saline Intraperitoneal Lavage
Saline intraperitoneal lavage mechanically irrigates and flushes the peritoneal cavity with sterile saline solution to remove debris, bacteria, and inflammatory mediators.
Saline intraperitoneal lavage mechanically irrigates and flushes the peritoneal cavity with sterile saline solution to remove debris, bacteria, and inflammatory mediators. Used for Peritonitis management, Intra-abdominal infection control during surgical procedures, Abdominal cavity cleansing.
At a glance
| Generic name | Saline Intraperitoneal Lavage |
|---|---|
| Also known as | normal saline, 0.9% Sodium Chloride, Saline Solution |
| Sponsor | Instituto Mexicano del Seguro Social |
| Modality | Small molecule |
| Therapeutic area | Surgery/Critical Care |
| Phase | FDA-approved |
Mechanism of action
This is a procedural intervention rather than a pharmacological drug. Sterile saline is instilled into the peritoneal cavity and then drained to cleanse the abdominal cavity. It is used to reduce bacterial load, remove particulate matter, and dilute inflammatory cytokines in peritonitis or during abdominal surgery. The mechanism is purely mechanical and osmotic, not receptor- or enzyme-based.
Approved indications
- Peritonitis management
- Intra-abdominal infection control during surgical procedures
- Abdominal cavity cleansing
Common side effects
- Electrolyte imbalance
- Hypothermia
- Peritoneal irritation
- Fluid overload
Key clinical trials
- Testing the Addition of Paclitaxel Administered Into the Abdominal Cavity Combined With Chemotherapy for Patients With Gastric Cancer Spread to the Abdominal Cavity (PHASE2, PHASE3)
- Does Intraperitoneal Washout Further Reduce Pain After Low-Pressure vNOTES Hysterectomy? (NA)
- Peritoneal Lavage Using Saline or Saline With Ondansetron for Pain Control After Laparoscopic Cholecystectomy (PHASE4)
- Comparing the Safety and Efficacy of First-line Polychemotherapy and Polychemotherapy in Combination With PIPAC Sessions (PHASE2)
- Irrisept in Emergency General Surgery Patients (PHASE4)
- Reduced-pressure Pneumoperitoneum and Intraperitoneal Saline Washout to Alleviate Pain Following vNOTES Hysterectomy (PHASE4)
- Pain with Differing Intraperitoneal Washes At the End of Laparoscopic Gynecologic Surgery (PHASE4)
- Treatment Strategy for Stage IV Gastric Cancer with Positive Peritoneal Cytology As the Only Non-curable Factor (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Saline Intraperitoneal Lavage CI brief — competitive landscape report
- Saline Intraperitoneal Lavage updates RSS · CI watch RSS
- Instituto Mexicano del Seguro Social portfolio CI