{"id":"saline-intraperitoneal-lavage","safety":{"commonSideEffects":[{"rate":null,"effect":"Electrolyte imbalance"},{"rate":null,"effect":"Hypothermia"},{"rate":null,"effect":"Peritoneal irritation"},{"rate":null,"effect":"Fluid overload"}]},"_chembl":{"chemblId":"CHEMBL2108783","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a procedural intervention rather than a pharmacological drug. Sterile saline is instilled into the peritoneal cavity and then drained to cleanse the abdominal cavity. It is used to reduce bacterial load, remove particulate matter, and dilute inflammatory cytokines in peritonitis or during abdominal surgery. The mechanism is purely mechanical and osmotic, not receptor- or enzyme-based.","oneSentence":"Saline intraperitoneal lavage mechanically irrigates and flushes the peritoneal cavity with sterile saline solution to remove debris, bacteria, and inflammatory mediators.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:06:33.874Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Peritonitis management"},{"name":"Intra-abdominal infection control during surgical procedures"},{"name":"Abdominal cavity cleansing"}]},"trialDetails":[{"nctId":"NCT07001748","phase":"PHASE2, PHASE3","title":"Testing the Addition of Paclitaxel Administered Into the Abdominal Cavity Combined With Chemotherapy for Patients With Gastric Cancer Spread to the Abdominal Cavity","status":"RECRUITING","sponsor":"ECOG-ACRIN Cancer Research Group","startDate":"2025-08-19","conditions":"Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Peritoneal Carcinomatosis","enrollment":148},{"nctId":"NCT07467577","phase":"NA","title":"Does Intraperitoneal Washout Further Reduce Pain After Low-Pressure vNOTES Hysterectomy?","status":"NOT_YET_RECRUITING","sponsor":"Erzincan Military Hospital","startDate":"2026-03-09","conditions":"Postoperative Pain, vNOTES","enrollment":94},{"nctId":"NCT06632184","phase":"PHASE4","title":"Peritoneal Lavage Using Saline or Saline With Ondansetron for Pain Control After Laparoscopic Cholecystectomy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Instituto Mexicano del Seguro Social","startDate":"2025-12-01","conditions":"Postoperative Pain Management, Laparoscopic Cholecystectomy, Ondansetron","enrollment":40},{"nctId":"NCT06313801","phase":"PHASE2","title":"Comparing the Safety and Efficacy of First-line Polychemotherapy and Polychemotherapy in Combination With PIPAC Sessions","status":"RECRUITING","sponsor":"Nizhny Novgorod Regional Clinical Oncology Center","startDate":"2023-01-19","conditions":"Gastric Cancer","enrollment":106},{"nctId":"NCT07048899","phase":"PHASE4","title":"Irrisept in Emergency General Surgery Patients","status":"ENROLLING_BY_INVITATION","sponsor":"The University of Texas Health Science Center at Tyler","startDate":"2024-09-04","conditions":"Emergency Surgery, Surgical Site Infections","enrollment":400},{"nctId":"NCT06944015","phase":"PHASE4","title":"Reduced-pressure Pneumoperitoneum and Intraperitoneal Saline Washout to Alleviate Pain Following vNOTES Hysterectomy","status":"NOT_YET_RECRUITING","sponsor":"Erzincan Military Hospital","startDate":"2025-04-24","conditions":"Pain, Inflammatory, Pain Management","enrollment":94},{"nctId":"NCT06842771","phase":"PHASE4","title":"Pain with Differing Intraperitoneal Washes At the End of Laparoscopic Gynecologic Surgery","status":"NOT_YET_RECRUITING","sponsor":"University of Tennessee","startDate":"2025-03","conditions":"Laparoscopic Adnexal Surgery","enrollment":96},{"nctId":"NCT02969122","phase":"NA","title":"Treatment Strategy for Stage IV Gastric Cancer with Positive Peritoneal Cytology As the Only Non-curable Factor","status":"TERMINATED","sponsor":"Peking University","startDate":"2016-11","conditions":"Stomach Neoplasm","enrollment":59},{"nctId":"NCT06491485","phase":"PHASE4","title":"Postoperative Analgesia in Laparoscopic Gynecological Surgeries","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2024-10-01","conditions":"Postoperative Pain","enrollment":90},{"nctId":"NCT01090882","phase":"NA","title":"Intraperitoneal Techniques of Local Anaesthesia During Laparoscopic Cholecystectomy","status":"COMPLETED","sponsor":"University Hospitals Coventry and Warwickshire NHS Trust","startDate":"2009-07","conditions":"Gall Stones","enrollment":128},{"nctId":"NCT05186467","phase":"PHASE2","title":"Pain After Laparoscopy Results From the Incision, Manipulation of the Abdominal Organs, and Retained CO2(Back Pain)","status":"UNKNOWN","sponsor":"Sohag University","startDate":"2021-09-02","conditions":"Post Operative Pain, Acute","enrollment":44},{"nctId":"NCT03290521","phase":"NA","title":"Intraperitoneal Lavage for Reducing Pain in Laparoscopy","status":"COMPLETED","sponsor":"Campus Bio-Medico University","startDate":"2018-07-01","conditions":"Pain, Postoperative","enrollment":277},{"nctId":"NCT03561948","phase":"NA","title":"Feasibility of Intraperitoneal Chemotherapy in the Surgical Treatment of Colon Cancer cT4","status":"COMPLETED","sponsor":"State Scientific Centre of Coloproctology, Russian Federation","startDate":"2018-01-09","conditions":"Colon Cancer","enrollment":90},{"nctId":"NCT01132755","phase":"PHASE2","title":"Rapid Gastric and Pancreas Cancer Staging Utilizing Peritoneal Lavage","status":"COMPLETED","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"2010-05","conditions":"Gastric Cancer, Pancreatic Cancer","enrollment":112},{"nctId":"NCT02154763","phase":"PHASE3","title":"The Use of Intraperitoneal Ropivacaine in Bariatric Bypass Surgery","status":"COMPLETED","sponsor":"Ottawa Hospital Research Institute","startDate":"2014-07","conditions":"Bariatric Surgery Candidate","enrollment":120},{"nctId":"NCT03004222","phase":"NA","title":"A Study to Determine the Effectiveness of Utilizing Intraperitoneal Bupivacaine","status":"COMPLETED","sponsor":"Metro Health, Michigan","startDate":"2015-07","conditions":"Laparoscopic Appendectomy","enrollment":137},{"nctId":"NCT01476553","phase":"NA","title":"Elimination of Peritoneal Tumor Cells With Extensive Peritoneal Lavage During Surgery in Patients With Gastric Cancer","status":"TERMINATED","sponsor":"Universitätsmedizin Mannheim","startDate":"2011-02","conditions":"Adenocarcinoma, Stomach Neoplasms","enrollment":30},{"nctId":"NCT02960061","phase":"PHASE3","title":"Perioperative Chemotherapy Combined With HIPEC for High-risk Advanced Gastric Cancer","status":"UNKNOWN","sponsor":"Sixth Affiliated Hospital, Sun Yat-sen University","startDate":"2016-11","conditions":"Survival","enrollment":640},{"nctId":"NCT02865993","phase":"NA","title":"Betadine Irrigation in Cesarean Section","status":"COMPLETED","sponsor":"Campus Bio-Medico University","startDate":"2015-09","conditions":"Infection; Cesarean Section","enrollment":80},{"nctId":"NCT02641288","phase":"PHASE3","title":"Intraperitoneal Ropivacaine Irrigation in Bariatric Surgery","status":"COMPLETED","sponsor":"Hospital General Universitario Elche","startDate":"2015-01","conditions":"Pain","enrollment":110},{"nctId":"NCT01608373","phase":"PHASE4","title":"The Effect of Intravenous Lidocaine and Intraperitoneal Lidocaine Irrigation on Pain After Laparoscopic Cholecystectomy","status":"UNKNOWN","sponsor":"Chung-Ang University Hosptial, Chung-Ang University College of Medicine","startDate":"2011-07","conditions":"Postoperative Pain","enrollment":83},{"nctId":"NCT01717222","phase":"PHASE4","title":"Effect of Intraperitoneal and Intravenous Lignocaine on Pain Relief Following Laparoscopic Cholecystectomy","status":"COMPLETED","sponsor":"Jawaharlal Institute of Postgraduate Medical Education & Research","startDate":"2011-12","conditions":"Pain, Postoperative, Analgesic Requirement, Stress Response","enrollment":50},{"nctId":"NCT01528722","phase":"NA","title":"Randomized Control Trial of Intraperitoneal Bupivacaine During Cholecystectomy","status":"COMPLETED","sponsor":"University Hospitals Coventry and Warwickshire NHS Trust","startDate":"2009-01","conditions":"Cholecystitis, Gall Stone Pancreatitis","enrollment":42}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":27,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["normal saline","0.9% Sodium Chloride","Saline Solution"],"phase":"marketed","status":"active","brandName":"Saline Intraperitoneal Lavage","genericName":"Saline Intraperitoneal Lavage","companyName":"Instituto Mexicano del Seguro Social","companyId":"instituto-mexicano-del-seguro-social","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Saline intraperitoneal lavage is a procedure where a saline solution is washed into the peritoneal cavity, and it has been studied as a potential diagnostic tool for various conditions, including gastric and pancreatic cancers, as well as postoperative pain. The exact mechanism of saline intraperitoneal lavage is unknown, but it has been used in clinical trials to compare against diagnostic peritoneal lavage and no washing at all.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":18,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}