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salbutamol + ipratropium bromide nebules
salbutamol + ipratropium bromide nebules is a Combination bronchodilator (beta-2 agonist + anticholinergic) Small molecule drug developed by Imperial College London. It is currently FDA-approved for Chronic obstructive pulmonary disease (COPD), Acute bronchospasm in obstructive airway disease. Also known as: albuterol, Ventolin, Atrovent, Albuterol.
Salbutamol and ipratropium bromide work together as a combination bronchodilator—salbutamol activates beta-2 adrenergic receptors to relax airway smooth muscle, while ipratropium blocks muscarinic acetylcholine receptors to prevent bronchoconstriction.
Salbutamol and ipratropium bromide work together as a combination bronchodilator—salbutamol activates beta-2 adrenergic receptors to relax airway smooth muscle, while ipratropium blocks muscarinic acetylcholine receptors to prevent bronchoconstriction. Used for Chronic obstructive pulmonary disease (COPD), Acute bronchospasm in obstructive airway disease.
At a glance
| Generic name | salbutamol + ipratropium bromide nebules |
|---|---|
| Also known as | albuterol, Ventolin, Atrovent, Albuterol |
| Sponsor | Imperial College London |
| Drug class | Combination bronchodilator (beta-2 agonist + anticholinergic) |
| Target | Beta-2 adrenergic receptor (salbutamol); M3 muscarinic acetylcholine receptor (ipratropium) |
| Modality | Small molecule |
| Therapeutic area | Respiratory |
| Phase | FDA-approved |
Mechanism of action
Salbutamol is a short-acting beta-2 agonist that increases intracellular cAMP, causing rapid airway smooth muscle relaxation. Ipratropium is an anticholinergic agent that blocks M3 muscarinic receptors on airway smooth muscle, preventing acetylcholine-induced constriction. Together, they provide complementary bronchodilation through different pathways, resulting in improved airflow and symptom relief in obstructive airway diseases.
Approved indications
- Chronic obstructive pulmonary disease (COPD)
- Acute bronchospasm in obstructive airway disease
Common side effects
- Tremor
- Headache
- Palpitations
- Dry mouth
- Nervousness
- Tachycardia
Key clinical trials
- A Comparative Study of Adding Ipratropium to Salbutamol for the Treatment of Asthma Attack in Children (PHASE4)
- Assessment of Ventilation-perfusion Abnormalities in Patients With Stable Smoking-related Airways Disease (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- salbutamol + ipratropium bromide nebules CI brief — competitive landscape report
- salbutamol + ipratropium bromide nebules updates RSS · CI watch RSS
- Imperial College London portfolio CI
Frequently asked questions about salbutamol + ipratropium bromide nebules
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Related
- Drug class: All Combination bronchodilator (beta-2 agonist + anticholinergic) drugs
- Target: All drugs targeting Beta-2 adrenergic receptor (salbutamol); M3 muscarinic acetylcholine receptor (ipratropium)
- Manufacturer: Imperial College London — full pipeline
- Therapeutic area: All drugs in Respiratory
- Indication: Drugs for Chronic obstructive pulmonary disease (COPD)
- Indication: Drugs for Acute bronchospasm in obstructive airway disease
- Also known as: albuterol, Ventolin, Atrovent, Albuterol
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