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Saccharomyces boulardi (Sb)
Saccharomyces boulardii is a live probiotic yeast that restores healthy gut microbiota and strengthens intestinal barrier function.
Saccharomyces boulardii is a live probiotic yeast that restores healthy gut microbiota and strengthens intestinal barrier function. Used for Acute diarrhea in children, Antibiotic-associated diarrhea, Traveler's diarrhea prevention and treatment.
At a glance
| Generic name | Saccharomyces boulardi (Sb) |
|---|---|
| Sponsor | Fundación Hospital de Pediatría Prof. Dr. Juan P. Garrahan |
| Drug class | Probiotic |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
S. boulardii colonizes the gastrointestinal tract and produces metabolites that inhibit pathogenic bacteria, reduce intestinal permeability, and modulate local immune responses. It also produces antimicrobial compounds and competes with harmful organisms for nutrients and adhesion sites on the intestinal epithelium.
Approved indications
- Acute diarrhea in children
- Antibiotic-associated diarrhea
- Traveler's diarrhea prevention and treatment
- Clostridium difficile-associated diarrhea
Common side effects
- Fungemia (rare, primarily in immunocompromised patients)
- Mild gastrointestinal symptoms
- Allergic reactions
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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