{"id":"saccharomyces-boulardi-sb","safety":{"commonSideEffects":[{"rate":null,"effect":"Fungemia (rare, primarily in immunocompromised patients)"},{"rate":null,"effect":"Mild gastrointestinal symptoms"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":{"chemblId":"CHEMBL1257246","moleculeType":"Small molecule","molecularWeight":"405.63"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"S. boulardii colonizes the gastrointestinal tract and produces metabolites that inhibit pathogenic bacteria, reduce intestinal permeability, and modulate local immune responses. It also produces antimicrobial compounds and competes with harmful organisms for nutrients and adhesion sites on the intestinal epithelium.","oneSentence":"Saccharomyces boulardii is a live probiotic yeast that restores healthy gut microbiota and strengthens intestinal barrier function.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:06:28.563Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute diarrhea in children"},{"name":"Antibiotic-associated diarrhea"},{"name":"Traveler's diarrhea prevention and treatment"},{"name":"Clostridium difficile-associated diarrhea"}]},"trialDetails":[{"nctId":"NCT07371819","phase":"PHASE4","title":"Effect of Saccharomyces Boulardii CNCM I-745 (Sb) on Bloody Diarrhea in Children. A Double Blind, Randomized, Controlled Study ( Sb192-SUH )","status":"ACTIVE_NOT_RECRUITING","sponsor":"Fundación Hospital de Pediatría Prof. Dr. Juan P. Garrahan","startDate":"2019-01-30","conditions":"Acute Bloody Diarrhea of 7 Days or Less Duration","enrollment":140}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Saccharomyces boulardi (Sb)","genericName":"Saccharomyces boulardi (Sb)","companyName":"Fundación Hospital de Pediatría Prof. Dr. Juan P. Garrahan","companyId":"fundaci-n-hospital-de-pediatr-a-prof-dr-juan-p-garrahan","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Saccharomyces boulardii is a live probiotic yeast that restores healthy gut microbiota and strengthens intestinal barrier function. Used for Acute diarrhea in children, Antibiotic-associated diarrhea, Traveler's diarrhea prevention and treatment.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}