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Ropivacaine + Tramadol
Ropivacaine blocks sodium channels to provide local anesthesia, while tramadol inhibits monoamine reuptake and activates opioid receptors to provide analgesia.
Ropivacaine blocks sodium channels to provide local anesthesia, while tramadol inhibits monoamine reuptake and activates opioid receptors to provide analgesia. Used for Local and regional anesthesia with postoperative pain management, Infiltration anesthesia for surgical procedures.
At a glance
| Generic name | Ropivacaine + Tramadol |
|---|---|
| Sponsor | Aga Khan University |
| Drug class | Local anesthetic + opioid analgesic combination |
| Target | Voltage-gated sodium channels (ropivacaine); mu-opioid receptor, norepinephrine transporter, serotonin transporter (tramadol) |
| Modality | Small molecule |
| Therapeutic area | Pain Management / Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Ropivacaine is a local anesthetic that reversibly blocks voltage-gated sodium channels in nerve fibers, preventing action potential propagation and sensory transmission in the infiltrated area. Tramadol is an analgesic that works through dual mechanisms: inhibition of norepinephrine and serotonin reuptake, and weak agonism at mu-opioid receptors. This combination provides both local anesthetic and systemic analgesic effects for pain management.
Approved indications
- Local and regional anesthesia with postoperative pain management
- Infiltration anesthesia for surgical procedures
Common side effects
- Nausea
- Dizziness
- Headache
- Local site reactions
- Drowsiness
Key clinical trials
- Opioid-Free Pain Protocol After Shoulder Arthroplasty (PHASE4)
- Tramadol / Magnesium in Ropivacaine Solution in UG-bilateral TAP Block and Analgesia in Robotic Radical Prostatectomy (NA)
- TAP Block With Lidocaine and Ropivacaine 0.2% (0.4 ml/kg/Side) for Pain and Opioid Reduction After Hysterectomy (NA)
- Erector Spinae Plane Block in Uniportal VATS
- Effect of Opioid-free Anesthesia on PostOperative Nausea and Vomiting in Patients Undergoing Video-assisted Thoracoscopic Surgery (NA)
- The Effect of Intravenous Infusion of Tramadol-ondansetron on Recovery After Caesarean Section.
- Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair (PHASE4)
- Fascia Iliaca Compartment Block and Tramadol for Analgesia in Hip Fracture (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ropivacaine + Tramadol CI brief — competitive landscape report
- Ropivacaine + Tramadol updates RSS · CI watch RSS
- Aga Khan University portfolio CI