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Ropivacaine + saline solution
Ropivacaine + saline solution is a Local anesthetic (amide class) Small molecule drug developed by Federal University of Minas Gerais. It is currently FDA-approved for Local infiltration anesthesia, Peripheral nerve blocks, Regional anesthesia procedures. Also known as: Naropin + saline solution.
Ropivacaine blocks sodium channels in nerve cell membranes to produce local anesthesia, with saline solution serving as the vehicle for delivery and dilution.
Ropivacaine is a small molecule used in medical interventions, including transversus abdominis plane blocks for conditions such as colorectal neoplasms, cardiac surgery, and acute pain. When combined with saline solution, ropivacaine is administered via transversus abdominis plane blocks in various clinical trials, including those for elderly patients undergoing abdominal surgery.
At a glance
| Generic name | Ropivacaine + saline solution |
|---|---|
| Also known as | Naropin + saline solution |
| Sponsor | Federal University of Minas Gerais |
| Drug class | Local anesthetic (amide class) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Ropivacaine is a long-acting amide local anesthetic that reversibly inhibits sodium influx into nerve fibers, preventing depolarization and action potential propagation. The saline solution formulation allows for appropriate concentration, osmolarity, and sterile delivery of the anesthetic agent to the site of administration. This combination is used for infiltration, nerve blocks, and regional anesthesia procedures.
Approved indications
- Local infiltration anesthesia
- Peripheral nerve blocks
- Regional anesthesia procedures
Common side effects
- Injection site reactions (pain, erythema)
- Systemic toxicity (CNS effects: dizziness, tinnitus, seizures)
- Cardiovascular effects (hypotension, bradycardia)
- Allergic reactions
Key clinical trials
- A Clinical Trial Evaluating the Efficacy, Safety, and Pharmacokinetic Profile of TRD303 for Postoperative Analgesia After Abdominal Surgery in China. (PHASE3)
- Does the Common Practice of Adding Diluted Epinephrine in Tranverse Abdominal Plan Block to Ropivacaine Significantly Decrease the Peak Systemic Resorption of Ropivacaine? (NA)
- CPL-01 in the Management of Postoperative Pain After Bunionectomy (PHASE3)
- PUSHES (Pudendal Block Versus Sacral ESP Hemorrhoidectomy Study) (NA)
- Herniorrhaphy for Postoperative Pain (PHASE3)
- Mid-transverse Process Combined With Erector Spinae Block Versus Paravertebral Plane Block (NA)
- Erector Spinae Plane Block for Acute Low Back Pain (NA)
- Perineural vs Intravenous Dexamethasone as an Adjuvant to Brachial Plexus Block in Pediatric Hand Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ropivacaine + saline solution CI brief — competitive landscape report
- Ropivacaine + saline solution updates RSS · CI watch RSS
- Federal University of Minas Gerais portfolio CI
Frequently asked questions about Ropivacaine + saline solution
What is Ropivacaine + saline solution?
How does Ropivacaine + saline solution work?
What is Ropivacaine + saline solution used for?
Who makes Ropivacaine + saline solution?
Is Ropivacaine + saline solution also known as anything else?
What drug class is Ropivacaine + saline solution in?
What development phase is Ropivacaine + saline solution in?
What are the side effects of Ropivacaine + saline solution?
What does Ropivacaine + saline solution target?
Related
- Drug class: All Local anesthetic (amide class) drugs
- Target: All drugs targeting Voltage-gated sodium channels
- Manufacturer: Federal University of Minas Gerais — full pipeline
- Therapeutic area: All drugs in Anesthesia
- Indication: Drugs for Local infiltration anesthesia
- Indication: Drugs for Peripheral nerve blocks
- Indication: Drugs for Regional anesthesia procedures
- Also known as: Naropin + saline solution
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing