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ropivacaine plus clonidine
Ropivacaine blocks sodium channels to provide local anesthesia, while clonidine enhances analgesia by activating alpha-2 adrenergic receptors.
Ropivacaine blocks sodium channels to provide local anesthesia, while clonidine enhances analgesia by activating alpha-2 adrenergic receptors. Used for Regional anesthesia and analgesia (peripheral nerve blocks, epidural anesthesia).
At a glance
| Generic name | ropivacaine plus clonidine |
|---|---|
| Sponsor | University Hospital, Lille |
| Drug class | Local anesthetic with adjuvant alpha-2 agonist |
| Target | Voltage-gated sodium channels (ropivacaine); alpha-2 adrenergic receptors (clonidine) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Ropivacaine is a long-acting amide local anesthetic that reversibly inhibits sodium influx in nerve fibers, preventing action potential generation and nerve conduction. Clonidine, an alpha-2 adrenergic agonist, potentiates the analgesic effect when combined with local anesthetics, likely through central and peripheral mechanisms including reduced catecholamine release and enhanced inhibitory neurotransmission. This combination is used to extend the duration and improve the quality of regional anesthesia.
Approved indications
- Regional anesthesia and analgesia (peripheral nerve blocks, epidural anesthesia)
Common side effects
- Hypotension
- Bradycardia
- Dizziness
- Dry mouth
- Sedation
- Nerve injury (from regional technique)
Key clinical trials
- Intrathecal MoRphine Versus Transabdominal Plane Block (TAP) Block for AnalGesic Management in Elective Caesarean Section (PHASE4)
- Combination of Nerve Blocks and Local Infiltration Analgesia in Knee Arthroplasty (PHASE4)
- Prospective Opioid-Free AIS Fusion (PHASE4)
- Clonidine in Ultrasound-guided Rectus Sheath Block for Outpatient Umbilical Hernioplasty (PHASE2, PHASE3)
- Effectiveness of Clonidine, Dexmedetomidine, and Fentanyl Adjuncts for Labor Epidural Analgesia (PHASE2)
- Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair (PHASE4)
- High Volume Caudal Study (EARLY_PHASE1)
- Efficacy of Intraoperative Injections on Postoperative Pain Control During Total Hip Replacement (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- ropivacaine plus clonidine CI brief — competitive landscape report
- ropivacaine plus clonidine updates RSS · CI watch RSS
- University Hospital, Lille portfolio CI