Last reviewed 2026-05-13 · How we verify

ropivacaine,morphine chloride,epinephrine,ketorolac

ropivacaine,morphine chloride,epinephrine,ketorolac is a Multimodal analgesic combination (local anesthetic + opioid + NSAID + sympathomimetic) Small molecule drug developed by Jose Antonio Bernia Gil. It is currently FDA-approved for Perioperative pain management and local anesthesia.

This is a combination analgesic and anesthetic formulation that blocks nerve conduction (ropivacaine), activates opioid receptors (morphine), increases sympathetic tone (epinephrine), and inhibits prostaglandin synthesis (ketorolac) to provide multimodal pain relief and local anesthesia.

This is a combination analgesic and anesthetic formulation that blocks nerve conduction (ropivacaine), activates opioid receptors (morphine), increases sympathetic tone (epinephrine), and inhibits prostaglandin synthesis (ketorolac) to provide multimodal pain relief and local anesthesia. Used for Perioperative pain management and local anesthesia.

At a glance

Mechanism of action

Ropivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing pain signal transmission. Morphine acts as a mu-opioid receptor agonist to provide systemic analgesia. Epinephrine causes vasoconstriction to prolong local anesthetic duration and reduce systemic absorption. Ketorolac is a nonsteroidal anti-inflammatory drug that inhibits cyclooxygenase enzymes to reduce inflammatory pain.

Approved indications

• Perioperative pain management and local anesthesia

Common side effects

• Nausea
• Dizziness
• Hypotension
• Tachycardia
• Local injection site reactions

Key clinical trials

• Opioid-Free Pain Protocol After Shoulder Arthroplasty (PHASE4)
• Prospective Opioid-Free AIS Fusion (PHASE4)
• Comparing Two Regional Anesthesia Interventions for Knee Arthroplasty. (NA)
• A Prospective Study on the Comparison of Postoperative Pain According to the Use of Cocktail Therapy in Laminoplasty (PHASE4)
• Perioperative Pain Management for Total Shoulder Arthroplasty: A Pilot Non-Inferiority Trial (NA)
• Local Infiltration Analgesia Vs. Interscalene Block in Total Shoulder Arthorplasty (NA)
• Periarticular Injection and Hamstring Block Versus Placebo for Pain Control in Anterior Cruciate Ligament Reconstruction (NA)
• Postoperative Pain Control After Periarticular Injection During Total Knee Arthroplasty (PHASE4)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• ropivacaine,morphine chloride,epinephrine,ketorolac CI brief — competitive landscape report
• ropivacaine,morphine chloride,epinephrine,ketorolac updates RSS · CI watch RSS
• Jose Antonio Bernia Gil portfolio CI

Frequently asked questions about ropivacaine,morphine chloride,epinephrine,ketorolac

Related

• Drug class: All Multimodal analgesic combination (local anesthetic + opioid + NSAID + sympathomimetic) drugs
• Target: All drugs targeting Sodium channels (ropivacaine), mu-opioid receptors (morphine), alpha/beta-adrenergic receptors (epinephrine), cyclooxygenase 1 and 2 (ketorolac)
• Manufacturer: Jose Antonio Bernia Gil — full pipeline
• Therapeutic area: All drugs in Pain Management / Anesthesia
• Indication: Drugs for Perioperative pain management and local anesthesia
• Compare: ropivacaine,morphine chloride,epinephrine,ketorolac vs similar drugs
• Pricing: ropivacaine,morphine chloride,epinephrine,ketorolac cost, discount & access