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ropivacaine mixed with dexmedetomidine
Ropivacaine blocks sodium channels to provide local anesthesia, while dexmedetomidine activates alpha-2 adrenergic receptors to enhance analgesia and sedation.
Ropivacaine blocks sodium channels to provide local anesthesia, while dexmedetomidine activates alpha-2 adrenergic receptors to enhance analgesia and sedation. Used for Regional anesthesia and analgesia for surgical procedures, Local infiltration anesthesia with enhanced analgesia.
At a glance
| Generic name | ropivacaine mixed with dexmedetomidine |
|---|---|
| Sponsor | The First Hospital of Qinhuangdao |
| Drug class | Local anesthetic combination with alpha-2 adrenergic agonist |
| Target | Voltage-gated sodium channels (ropivacaine); alpha-2 adrenergic receptors (dexmedetomidine) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia and Pain Management |
| Phase | FDA-approved |
Mechanism of action
Ropivacaine is a long-acting amide local anesthetic that reversibly inhibits sodium influx in nerve fibers, preventing action potential propagation and sensory/motor blockade. Dexmedetomidine is a selective alpha-2 adrenergic agonist that enhances the analgesic effect and provides sedation and anxiolysis when combined with local anesthetics, improving the quality and duration of regional anesthesia.
Approved indications
- Regional anesthesia and analgesia for surgical procedures
- Local infiltration anesthesia with enhanced analgesia
Common side effects
- Hypotension
- Bradycardia
- Sedation
- Dry mouth
- Transient hypertension
Key clinical trials
- Contrast and Anesthetic Level With Lumbar Erector Spinae Plan (ESP) Block (NA)
- COMPARISON OF MEAN DURATION OF POST OPERATIVE ANALGESIA FOLLOWING ADDITION OF DEXMEDETOMIDINE TO ROPIVACAINE VERSUS PLAIN ROPIVACAINE ON ULTRASOUND GUIDED RECTUS SHEATH BLOCK (NA)
- Intravenous Lidocaine Plus Intratracheal Dexmedetomidine on Postoperative Sore Throat (NA)
- Adjuncts for Adductor Block: Dexamethasone,Dexmedetomidine, or Combination to Reduce Pain (PHASE4)
- Dexmedetomidine Added to Ropivacaine Single Shot vs Continuous Interscalene Nerve Block (NA)
- the Effect of Dexmedetomidine in Coracoid Approach Brachial Plexus Block (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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