{"id":"ropivacaine-mixed-with-dexmedetomidine","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Transient hypertension"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ropivacaine is a long-acting amide local anesthetic that reversibly inhibits sodium influx in nerve fibers, preventing action potential propagation and sensory/motor blockade. Dexmedetomidine is a selective alpha-2 adrenergic agonist that enhances the analgesic effect and provides sedation and anxiolysis when combined with local anesthetics, improving the quality and duration of regional anesthesia.","oneSentence":"Ropivacaine blocks sodium channels to provide local anesthesia, while dexmedetomidine activates alpha-2 adrenergic receptors to enhance analgesia and sedation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:37:23.688Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Regional anesthesia and analgesia for surgical procedures"},{"name":"Local infiltration anesthesia with enhanced analgesia"}]},"trialDetails":[{"nctId":"NCT07174440","phase":"NA","title":"Contrast and Anesthetic Level With Lumbar Erector Spinae Plan (ESP) Block","status":"RECRUITING","sponsor":"University Hospitals Cleveland Medical Center","startDate":"2025-09-15","conditions":"Pain","enrollment":32},{"nctId":"NCT07254130","phase":"NA","title":"COMPARISON OF MEAN DURATION OF POST OPERATIVE ANALGESIA FOLLOWING ADDITION OF DEXMEDETOMIDINE TO ROPIVACAINE VERSUS PLAIN ROPIVACAINE ON ULTRASOUND GUIDED RECTUS SHEATH BLOCK","status":"COMPLETED","sponsor":"Quaid-e-Azam Medical College","startDate":"2025-02-28","conditions":"Midline Laparotomy","enrollment":209},{"nctId":"NCT06952309","phase":"NA","title":"Intravenous Lidocaine Plus Intratracheal Dexmedetomidine on Postoperative Sore Throat","status":"NOT_YET_RECRUITING","sponsor":"Anqing Municipal Hospital","startDate":"2025-04-25","conditions":"Dexmedetomidine, Lidocaine, Sore Throat","enrollment":144},{"nctId":"NCT03643822","phase":"PHASE4","title":"Adjuncts for Adductor Block: Dexamethasone,Dexmedetomidine, or Combination to Reduce Pain","status":"RECRUITING","sponsor":"Women's College Hospital","startDate":"2020-02-21","conditions":"ACL Injury","enrollment":252},{"nctId":"NCT05775861","phase":"NA","title":"Dexmedetomidine Added to Ropivacaine Single Shot vs Continuous Interscalene Nerve Block","status":"UNKNOWN","sponsor":"Ciusss de L'Est de l'Île de Montréal","startDate":"2022-08-23","conditions":"Anesthesia, Shoulder Pain, Post Operative Pain","enrollment":96},{"nctId":"NCT02961361","phase":"PHASE4","title":"the Effect of Dexmedetomidine in Coracoid Approach Brachial Plexus Block","status":"COMPLETED","sponsor":"The First Hospital of Qinhuangdao","startDate":"2016-11-12","conditions":"Injury of Upper Limb","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"ropivacaine mixed with dexmedetomidine","genericName":"ropivacaine mixed with dexmedetomidine","companyName":"The First Hospital of Qinhuangdao","companyId":"the-first-hospital-of-qinhuangdao","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ropivacaine blocks sodium channels to provide local anesthesia, while dexmedetomidine activates alpha-2 adrenergic receptors to enhance analgesia and sedation. Used for Regional anesthesia and analgesia for surgical procedures, Local infiltration anesthesia with enhanced analgesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}