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Ropivacaine, Ketorolac and Adrenaline
Ropivacaine, Ketorolac and Adrenaline is a Local anesthetic combination with NSAID and vasopressor Small molecule drug developed by University of Aarhus. It is currently FDA-approved for Local infiltration anesthesia and perioperative pain management, Surgical site anesthesia with hemostasis.
This combination provides local anesthesia via sodium channel blockade (ropivacaine), pain relief through COX inhibition (ketorolac), and vasoconstriction with sympathomimetic effects (adrenaline).
This combination provides local anesthesia via sodium channel blockade (ropivacaine), pain relief through COX inhibition (ketorolac), and vasoconstriction with sympathomimetic effects (adrenaline). Used for Local infiltration anesthesia and perioperative pain management, Surgical site anesthesia with hemostasis.
At a glance
| Generic name | Ropivacaine, Ketorolac and Adrenaline |
|---|---|
| Sponsor | University of Aarhus |
| Drug class | Local anesthetic combination with NSAID and vasopressor |
| Target | Voltage-gated sodium channels (ropivacaine); COX-1 and COX-2 (ketorolac); alpha and beta adrenergic receptors (adrenaline) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia and Pain Management |
| Phase | FDA-approved |
Mechanism of action
Ropivacaine is a long-acting amide local anesthetic that blocks sodium channels in nerve membranes, preventing action potential propagation. Ketorolac is a non-selective NSAID that inhibits cyclooxygenase enzymes to reduce prostaglandin-mediated inflammation and pain. Adrenaline acts as a sympathomimetic agent causing vasoconstriction, which prolongs local anesthetic duration and reduces systemic absorption and bleeding.
Approved indications
- Local infiltration anesthesia and perioperative pain management
- Surgical site anesthesia with hemostasis
Common side effects
- Local tissue irritation or inflammation
- Systemic toxicity from local anesthetic (CNS or cardiac)
- Gastrointestinal effects from ketorolac
- Tachycardia or hypertension from adrenaline
- Allergic reaction
Key clinical trials
- Opioid-Free Pain Protocol After Shoulder Arthroplasty (PHASE4)
- Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery. (PHASE2, PHASE3)
- Prospective Opioid-Free AIS Fusion (PHASE4)
- Effect of RECK in Posterior Spinal Fusion (PHASE1, PHASE2)
- LIA vs. LIA + ACB-iPACK Block for Total Knee Arthroplasty (NA)
- Effects Of Intra-Operative Intra-Articular Cocktail Injection In Patella Open Reduction And Internal Fixation (PHASE4)
- Periarticular Bupivacaine + Meloxicam ER Solution Versus Standard Practice During Total Knee Arthroplasty (PHASE4)
- Pain Injection Versus Epidural Anesthesia for Hip Surgery in Pediatric Patients With Cerebral Palsy (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ropivacaine, Ketorolac and Adrenaline CI brief — competitive landscape report
- Ropivacaine, Ketorolac and Adrenaline updates RSS · CI watch RSS
- University of Aarhus portfolio CI
Frequently asked questions about Ropivacaine, Ketorolac and Adrenaline
What is Ropivacaine, Ketorolac and Adrenaline?
How does Ropivacaine, Ketorolac and Adrenaline work?
What is Ropivacaine, Ketorolac and Adrenaline used for?
Who makes Ropivacaine, Ketorolac and Adrenaline?
What drug class is Ropivacaine, Ketorolac and Adrenaline in?
What development phase is Ropivacaine, Ketorolac and Adrenaline in?
What are the side effects of Ropivacaine, Ketorolac and Adrenaline?
What does Ropivacaine, Ketorolac and Adrenaline target?
Related
- Drug class: All Local anesthetic combination with NSAID and vasopressor drugs
- Target: All drugs targeting Voltage-gated sodium channels (ropivacaine); COX-1 and COX-2 (ketorolac); alpha and beta adrenergic receptors (adrenaline)
- Manufacturer: University of Aarhus — full pipeline
- Therapeutic area: All drugs in Anesthesia and Pain Management
- Indication: Drugs for Local infiltration anesthesia and perioperative pain management
- Indication: Drugs for Surgical site anesthesia with hemostasis
- Compare: Ropivacaine, Ketorolac and Adrenaline vs similar drugs
- Pricing: Ropivacaine, Ketorolac and Adrenaline cost, discount & access