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Ropivacaine infiltration

University Hospital, Lille · Phase 3 active Small molecule

Ropivacaine infiltration is a Local anesthetic (amide) Small molecule drug developed by University Hospital, Lille. It is currently in Phase 3 development for Local infiltration anesthesia for surgical procedures, Regional anesthesia and nerve blocks. Also known as: Naropin, local anesthetic.

Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.

Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. Used for Local infiltration anesthesia for surgical procedures, Regional anesthesia and nerve blocks.

At a glance

Generic nameRopivacaine infiltration
Also known asNaropin, local anesthetic
SponsorUniversity Hospital, Lille
Drug classLocal anesthetic (amide)
TargetVoltage-gated sodium channels
ModalitySmall molecule
Therapeutic areaAnesthesia
PhasePhase 3

Mechanism of action

Ropivacaine reversibly inhibits sodium influx through voltage-gated sodium channels in nerve fibers, thereby preventing depolarization and transmission of nerve impulses. This results in local anesthesia at the site of infiltration. As a long-acting amide local anesthetic, it provides prolonged anesthesia with a favorable safety profile compared to some alternatives.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about Ropivacaine infiltration

What is Ropivacaine infiltration?

Ropivacaine infiltration is a Local anesthetic (amide) drug developed by University Hospital, Lille, indicated for Local infiltration anesthesia for surgical procedures, Regional anesthesia and nerve blocks.

How does Ropivacaine infiltration work?

Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.

What is Ropivacaine infiltration used for?

Ropivacaine infiltration is indicated for Local infiltration anesthesia for surgical procedures, Regional anesthesia and nerve blocks.

Who makes Ropivacaine infiltration?

Ropivacaine infiltration is developed by University Hospital, Lille (see full University Hospital, Lille pipeline at /company/university-hospital-lille).

Is Ropivacaine infiltration also known as anything else?

Ropivacaine infiltration is also known as Naropin, local anesthetic.

What drug class is Ropivacaine infiltration in?

Ropivacaine infiltration belongs to the Local anesthetic (amide) class. See all Local anesthetic (amide) drugs at /class/local-anesthetic-amide.

What development phase is Ropivacaine infiltration in?

Ropivacaine infiltration is in Phase 3.

What are the side effects of Ropivacaine infiltration?

Common side effects of Ropivacaine infiltration include Injection site reactions (pain, erythema), Transient neurological symptoms, Systemic toxicity (CNS and cardiac effects at high doses).

What does Ropivacaine infiltration target?

Ropivacaine infiltration targets Voltage-gated sodium channels and is a Local anesthetic (amide).

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