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Ropivacaine 0.4%
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local and regional anesthesia for surgery and acute pain management, Peripheral nerve blocks, Epidural anesthesia.
At a glance
| Generic name | Ropivacaine 0.4% |
|---|---|
| Also known as | continuous peripheral nerve block |
| Sponsor | University of California, San Diego |
| Drug class | Local anesthetic (amide) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Ropivacaine reversibly binds to and blocks voltage-gated sodium channels on the inner surface of nerve cell membranes, preventing depolarization and action potential propagation. This results in a loss of sensation in the area where it is administered. It is an amide-type local anesthetic with a long duration of action and lower cardiotoxicity compared to some other local anesthetics.
Approved indications
- Local and regional anesthesia for surgery and acute pain management
- Peripheral nerve blocks
- Epidural anesthesia
Common side effects
- Hypotension
- Bradycardia
- Nausea
- Headache
- Dizziness
- Systemic toxicity (CNS and cardiac effects at high doses)
Key clinical trials
- Intravenous Lidocaine Plus Port-Site Ropivacaine for Recovery After Laparoscopic Surgery (PHASE3)
- Tegileridine Combined With Intercostal Nerve Block After Thoracoscopic Lung Resection (NA)
- Ropiclobet for Regional Anesthesia and Post-Operative Pain Control in Upper Extremity Surgery (PHASE2)
- Serratus Anterior or Erector Spinae Block for Hybrid Arrhythmia Ablation Surgery (NA)
- Effect of the PIEB Versus CEI on the Quality of Postoperative Recovery in Patients Undergoing VATS Lobectomy (NA)
- Intercostal Nerve Cryoanalgesia vs BRILMA Block for Minithoracotomy on Cardiac Surgery
- Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies (NA)
- QLESP Block Versus Periarticular Infiltration for Postoperative Analgesia in Hip Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ropivacaine 0.4% CI brief — competitive landscape report
- Ropivacaine 0.4% updates RSS · CI watch RSS
- University of California, San Diego portfolio CI