{"id":"ropivacaine-0-4","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Systemic toxicity (CNS and cardiac effects at high doses)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ropivacaine reversibly binds to and blocks voltage-gated sodium channels on the inner surface of nerve cell membranes, preventing depolarization and action potential propagation. This results in a loss of sensation in the area where it is administered. It is an amide-type local anesthetic with a long duration of action and lower cardiotoxicity compared to some other local anesthetics.","oneSentence":"Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:05:46.289Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local and regional anesthesia for surgery and acute pain management"},{"name":"Peripheral nerve blocks"},{"name":"Epidural anesthesia"}]},"trialDetails":[{"nctId":"NCT07414706","phase":"PHASE3","title":"Intravenous Lidocaine Plus Port-Site Ropivacaine for Recovery After Laparoscopic Surgery","status":"NOT_YET_RECRUITING","sponsor":"Centre Hospitalier Universitaire, Amiens","startDate":"2026-03","conditions":"Intravenous Lidocaine, Laparoscopic Surgery, Post Operative Recovery","enrollment":182},{"nctId":"NCT07386626","phase":"NA","title":"Tegileridine Combined With Intercostal Nerve Block After Thoracoscopic Lung Resection","status":"NOT_YET_RECRUITING","sponsor":"Tongji Hospital","startDate":"2026-02-09","conditions":"Lobectomy","enrollment":118},{"nctId":"NCT07131657","phase":"PHASE2","title":"Ropiclobet for Regional Anesthesia and Post-Operative Pain Control in Upper Extremity Surgery","status":"COMPLETED","sponsor":"PHARMAFINA","startDate":"2025-09-02","conditions":"Nerve Block, Upper Extremity Surgery","enrollment":40},{"nctId":"NCT04868058","phase":"NA","title":"Serratus Anterior or Erector Spinae Block for Hybrid Arrhythmia Ablation Surgery","status":"TERMINATED","sponsor":"Universitair Ziekenhuis Brussel","startDate":"2020-10-02","conditions":"Arrhythmia","enrollment":28},{"nctId":"NCT05930405","phase":"NA","title":"Effect of the PIEB Versus CEI on the Quality of Postoperative Recovery in Patients Undergoing VATS Lobectomy","status":"COMPLETED","sponsor":"Sun Yat-sen University","startDate":"2023-10-20","conditions":"Video-assisted Thoracic Surgery","enrollment":252},{"nctId":"NCT06086535","phase":"","title":"Intercostal Nerve Cryoanalgesia vs BRILMA Block for Minithoracotomy on Cardiac Surgery","status":"COMPLETED","sponsor":"Hospital Universitari Vall d'Hebron Research Institute","startDate":"2023-10-30","conditions":"Post Operative Pain","enrollment":63},{"nctId":"NCT05279898","phase":"NA","title":"Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies","status":"COMPLETED","sponsor":"Beth Israel Deaconess Medical Center","startDate":"2023-02-28","conditions":"Postoperative Delirium, Hemodynamic Instability, Pain","enrollment":70},{"nctId":"NCT06688136","phase":"NA","title":"QLESP Block Versus Periarticular Infiltration for Postoperative Analgesia in Hip Surgery","status":"COMPLETED","sponsor":"Huazhong University of Science and Technology","startDate":"2024-11-18","conditions":"Regional Anaesthesia","enrollment":68},{"nctId":"NCT07145775","phase":"PHASE4","title":"Dexmedetomidine-esketamine-ropivacaine Versus Sufentanil-ropivacaine for Epidural Labor Analgesia","status":"NOT_YET_RECRUITING","sponsor":"Peking University First Hospital","startDate":"2025-08","conditions":"Epidural Analgesia, Labor Pain, Sufentanil","enrollment":300},{"nctId":"NCT07139691","phase":"NA","title":"TAP Block With Lidocaine and Ropivacaine 0.2% (0.4 ml/kg/Side) for Pain and Opioid Reduction After Hysterectomy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Matild Keresztes","startDate":"2024-01-12","conditions":"Postoperative Pain Following Hysterectomy","enrollment":82},{"nctId":"NCT07023094","phase":"PHASE4","title":"PENG With LFCB vs. ESP Blocks for Pediatric Hip Surgery","status":"RECRUITING","sponsor":"Poznan University of Medical Sciences","startDate":"2025-06-16","conditions":"Hip Disease, Hip Dysplasia, Hip Arthropathy","enrollment":60},{"nctId":"NCT06903182","phase":"NA","title":"Preoperative TAP Block Versus Postoperative TAP Block in Patients Undergoing Laparoscopic Cholecystectomy: a Randomized Controlled Trial","status":"RECRUITING","sponsor":"University of Padova","startDate":"2025-06-16","conditions":"TAP Block","enrollment":46},{"nctId":"NCT06878391","phase":"NA","title":"ISB With SSNB & ANB","status":"RECRUITING","sponsor":"Chuncheon Sacred Heart Hospital","startDate":"2025-03-24","conditions":"Rotator Cuff Tear","enrollment":100},{"nctId":"NCT06781632","phase":"PHASE1","title":"Phase I Study of Ropivacaine, Clonidine, and Betamethasone Combination for Sciatic Nerve Block in the Popliteal Region","status":"COMPLETED","sponsor":"PHARMAFINA","startDate":"2024-11-13","conditions":"Healthy, Nerve Block","enrollment":12},{"nctId":"NCT06883370","phase":"PHASE4","title":"Analgesia Evaluation of an Ultrasound-guided Technique for Inguinal Hernia Surgery in Children in Children","status":"COMPLETED","sponsor":"National University of Malaysia","startDate":"2023-12-01","conditions":"Inguinal Hernia, Surgery, Paediatric","enrollment":32},{"nctId":"NCT06862947","phase":"NA","title":"Ultrasound-Guided Rectus Sheath Block in Gynecological Single-Port Laparoscopy","status":"COMPLETED","sponsor":"Chengdu Jinjiang Maternity and Child Health Hospital","startDate":"2022-04-26","conditions":"Gynecological Laparoscopy, Postoperative Pain, Rectus Sheath Block","enrollment":90},{"nctId":"NCT06816173","phase":"PHASE4","title":"Effect of Propofol Versus Remimazolam Intravenous Anesthesia on Respiratory Depression","status":"NOT_YET_RECRUITING","sponsor":"Second Affiliated Hospital of Wenzhou Medical University","startDate":"2025-02","conditions":"Respiratory Depression","enrollment":96},{"nctId":"NCT06557018","phase":"PHASE4","title":"Efficacy and Safety of Liposomal Bupivacaine Using Periarticular Injection in Total Knee Arthroplasty","status":"RECRUITING","sponsor":"Dezhou Hospital Qilu Hospital of Shandong University","startDate":"2024-06-25","conditions":"Osteoarthritis, Knee","enrollment":60},{"nctId":"NCT02712151","phase":"PHASE3","title":"Efficacy of Transversus Abdominis Plane Block for Laparoscopic Cholecystectomy","status":"WITHDRAWN","sponsor":"Boston Children's Hospital","startDate":"2024-03-01","conditions":"Pain, Postoperative","enrollment":""},{"nctId":"NCT05837013","phase":"NA","title":"Open and Laparoscopic Total Extraperitoneal Repair Under Spinal Anesthesia Versus General Anesthesia","status":"COMPLETED","sponsor":"Konya City Hospital","startDate":"2023-09-20","conditions":"Pain, Postoperative, Postoperative Complications, Inguinal Hernia","enrollment":34},{"nctId":"NCT06199011","phase":"NA","title":"Effect of Esketamine on Depressive Symptoms of Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy","status":"UNKNOWN","sponsor":"The Second Hospital of Anhui Medical University","startDate":"2024-01-01","conditions":"Depressive Symptoms","enrollment":400},{"nctId":"NCT06036797","phase":"PHASE2","title":"Efficacy and Safety of Hydromorphone-ropivacaine Versus Sufentanil-ropivacaine for Epidural Labor Analgesia","status":"UNKNOWN","sponsor":"Maternal and Child Health Hospital of Hubei Province","startDate":"2023-09-17","conditions":"Analgesia, Labor Pain","enrollment":240},{"nctId":"NCT06055478","phase":"NA","title":"Effect of Suprascapular Nerve Block and Axillary Nerve Block After Arthroscopic Rotator Cuff Repair","status":"UNKNOWN","sponsor":"Chuncheon Sacred Heart Hospital","startDate":"2023-09-25","conditions":"Rotator Cuff Tears","enrollment":100},{"nctId":"NCT02369523","phase":"EARLY_PHASE1","title":"Multimodal Pain Management Following Primary TKA","status":"TERMINATED","sponsor":"University of Utah","startDate":"2014-09","conditions":"Pain","enrollment":84},{"nctId":"NCT05964985","phase":"NA","title":"Effect of Quadratus Lumborum Block With Compound Lidocaine and Esketamine on Pain After Colorectal Surgery","status":"UNKNOWN","sponsor":"Tianjin Medical University General Hospital","startDate":"2023-08-06","conditions":"Postoperative Pain","enrollment":160},{"nctId":"NCT05538429","phase":"NA","title":"Comparison of Analgesic Effect and Postoperative Recovery of SAPB Combined With ESPB and TPB After Thoracoscopic Surgery","status":"UNKNOWN","sponsor":"Zhangyi","startDate":"2021-06-01","conditions":"Thoracoscopic Surgery, Nerve Block","enrollment":92},{"nctId":"NCT04390698","phase":"NA","title":"Opioid Free Anesthesia in Breast Cancer Surgery","status":"COMPLETED","sponsor":"Peking University People's Hospital","startDate":"2020-07-01","conditions":"Opioid Free Anesthesia","enrollment":80},{"nctId":"NCT04767256","phase":"NA","title":"Intravenous Dexamethasone and Dexmedetomidine on the Analgesic Efficacy of Erector Spinae Plane Block","status":"COMPLETED","sponsor":"Huazhong University of Science and Technology","startDate":"2021-03-01","conditions":"Dexamethasone, Dexmedetomidine, Nerve Block","enrollment":120},{"nctId":"NCT04938882","phase":"NA","title":"Effect of Transversus Abdominis Plane Block With Compound Lidocaine on Pain After Gynecological Surgery","status":"COMPLETED","sponsor":"Tianjin Medical University General Hospital","startDate":"2021-08-15","conditions":"Postoperative Pain","enrollment":164},{"nctId":"NCT04705974","phase":"NA","title":"MED90 of Ropivacaine for Peripheral Nerve Block on Posture-evoked Pain in Spinal Anesthesia Positioning","status":"UNKNOWN","sponsor":"Huazhong University of Science and Technology","startDate":"2022-01-25","conditions":"Hip Fractures","enrollment":180},{"nctId":"NCT05122338","phase":"NA","title":"Effect of Transversus Abdominis Plane Block With Compound Lidocaine and Esketamine on Pain After Surgery","status":"UNKNOWN","sponsor":"Tianjin Medical University General Hospital","startDate":"2021-12-01","conditions":"Postoperative Pain","enrollment":160},{"nctId":"NCT04726878","phase":"PHASE4","title":"ESP in Breast Surgery Due to Cancer","status":"COMPLETED","sponsor":"Medical University of Lublin","startDate":"2021-02-01","conditions":"Breast Cancer, Pain, Acute, Anesthesia, Local","enrollment":75},{"nctId":"NCT04521556","phase":"PHASE4","title":"Effect of Epidural Anesthesia and Analgesia on Quality of Recovery After Unilateral Nephrectomy.","status":"COMPLETED","sponsor":"University Hospital of Split","startDate":"2019-04-01","conditions":"Anesthesia, Anesthesia Recovery Period, Nephrectomy","enrollment":80},{"nctId":"NCT04587505","phase":"PHASE4","title":"Effect of Epidural Anesthesia and Analgesia on Quality of Recovery After Radical Prostatectomy.","status":"COMPLETED","sponsor":"University Hospital of Split","startDate":"2019-04-01","conditions":"Anesthesia, Anesthesia Recovery Period, Radical Prostatectomy","enrollment":61},{"nctId":"NCT04306159","phase":"NA","title":"Application of Rectus Sheath Block based-on Incision in Upper Abdominal Surgery","status":"COMPLETED","sponsor":"The First Affiliated Hospital of Anhui Medical University","startDate":"2020-03-15","conditions":"Opioid Consumption","enrollment":126},{"nctId":"NCT03975296","phase":"NA","title":"QLB Versus PVB for Acute Pain and Quality of Recovery After Laparoscopic Partial Nephrectomy","status":"COMPLETED","sponsor":"Cui Xulei","startDate":"2019-06-10","conditions":"Nerve Block, Nephrectomy, Analgesia","enrollment":60},{"nctId":"NCT01898689","phase":"PHASE4","title":"Optimizing Local Anesthetic Concentration for Continuous Popliteal-Sciatic Nerve Blocks","status":"COMPLETED","sponsor":"University of California, San Diego","startDate":"2013-07","conditions":"Relatively Healthy Volunteers","enrollment":24},{"nctId":"NCT00912873","phase":"PHASE4","title":"Optimizing Local Anesthetic Concentration for Continuous Lumbar Plexus Nerve Blocks","status":"COMPLETED","sponsor":"University of California, San Diego","startDate":"2008-05","conditions":"Hip Arthroplasty, Hip Pain","enrollment":50},{"nctId":"NCT04077398","phase":"PHASE4","title":"Volume vs Concentration: Quadratus Lumborum Blocks With High Volume/Low Concentration or Low Volume/ High Concentration in Nephrectomies","status":"WITHDRAWN","sponsor":"Bruce Ben-David","startDate":"2020-01-22","conditions":"Analgesia, Postoperative Pain, Block","enrollment":""},{"nctId":"NCT03260283","phase":"PHASE2, PHASE3","title":"Assessment of Subarachnoid Anesthesia With Low Dose of Pethidine and Combination of Ropivacaine With Fentanyl for Urologic Surgical Operations.","status":"COMPLETED","sponsor":"Saint Savvas Anticancer Hospital","startDate":"2017-08-16","conditions":"Low Dose of Pethidine for Subarachnoid Anesthesia","enrollment":104},{"nctId":"NCT03414281","phase":"NA","title":"TMQLB Versus TPVB for Acute Pain and Quality of Recovery After Laparoscopic Renal Surgery","status":"TERMINATED","sponsor":"Cui Xulei","startDate":"2019-01-04","conditions":"Nerve Block, Nephrectomy, Analgesia","enrollment":30},{"nctId":"NCT00768248","phase":"NA","title":"Naval Medical Center San Diego (NMCSD) - Ambulatory Continuous Peripheral Nerve Blocks for Treatment of Post-Amputation Phantom Limb and Stump Pain","status":"TERMINATED","sponsor":"University of California, San Diego","startDate":"2008-10","conditions":"Amputation, Phantom Limb, Stump Pain","enrollment":2},{"nctId":"NCT02311517","phase":"NA","title":"The Effects of Serratus Anterior Plane Block on Postoperative Quality of Recovery and Analgesia After Video-assisted Thoracoscopic Surgery","status":"COMPLETED","sponsor":"Yonsei University","startDate":"2014-01-28","conditions":"Postoperative Quality of Recovery and Analgesia After Video-assisted Thoracoscopic Surgery","enrollment":90},{"nctId":"NCT01971645","phase":"PHASE3","title":"Decadron as Adjuvant in Femoral Nerve Blocks in Knee Arthroscopy","status":"COMPLETED","sponsor":"Nationwide Children's Hospital","startDate":"2014-07","conditions":"Knee Injury","enrollment":77},{"nctId":"NCT03203967","phase":"NA","title":"Epidural Morphine for Postoperative Analgesia After Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Peking University First Hospital","startDate":"2017-07-01","conditions":"Adult Patients, Total Knee Arthroplasty, Epidural Analgesia","enrollment":110},{"nctId":"NCT00771862","phase":"PHASE4","title":"Prevention of Phantom Limb and Stump Pain Using Ambulatory Continuous Peripheral Nerve Blocks: A Pilot Study","status":"TERMINATED","sponsor":"University of California, San Diego","startDate":"2008-10","conditions":"Amputation, Phantom Limb Pain, Stump Pain","enrollment":16},{"nctId":"NCT02920489","phase":"NA","title":"Individualized Timing of Analgesia and Effectiveness of Labor Analgesia","status":"COMPLETED","sponsor":"Peking University First Hospital","startDate":"2016-08","conditions":"Labor Pain, Analgesia, Obstetrical, Early Medical Intervention","enrollment":200},{"nctId":"NCT02873091","phase":"NA","title":"Comparison of Programmed Intermittent Epidural Bolus With Continuous Epidural Infusion for Labor Epidural Analgesia","status":"UNKNOWN","sponsor":"Nanjing Maternity and Child Health Care Hospital","startDate":"2016-09","conditions":"Labor Analgesia","enrollment":186},{"nctId":"NCT01615939","phase":"PHASE4","title":"A Study Comparing Continuous Sciatic Nerve Block to Single Shot Sciatic Nerve Block","status":"TERMINATED","sponsor":"Northwestern University","startDate":"2012-06","conditions":"Fracture of Foot","enrollment":17},{"nctId":"NCT01700491","phase":"PHASE3","title":"Pilot Study: Paravertebral Analgesia vs Epidural Analgesia After Thoracotomy","status":"TERMINATED","sponsor":"University of Manitoba","startDate":"2012-10","conditions":"Hypotension","enrollment":21},{"nctId":"NCT02259374","phase":"NA","title":"Use of Tap Block in Patients After Hysterectomy","status":"UNKNOWN","sponsor":"Singapore General Hospital","startDate":"2014-10","conditions":"Abdominal Hysterectomy (& Wertheim)","enrollment":54},{"nctId":"NCT02135224","phase":"NA","title":"the Effects of Epidural Fentanyl on Vaginal Delivery","status":"UNKNOWN","sponsor":"University of Athens","startDate":"2011-12","conditions":"Cervical Dilatation, Bishop Score, Duration of Delivery","enrollment":60},{"nctId":"NCT01782612","phase":"NA","title":"The Assessments of the Postoperative Recovery on Elderly Patients Received General Anesthesia or Peripheral Nerve Blocks","status":"UNKNOWN","sponsor":"Junle Liu","startDate":"2013-03","conditions":"Anesthesia, Hip Osteoarthritis","enrollment":100},{"nctId":"NCT00667264","phase":"NA","title":"Ambulatory Continuous Peripheral Nerve Blocks for Treatment of Post-Amputation Phantom Limb and Stump Pain","status":"COMPLETED","sponsor":"University of California, San Diego","startDate":"2008-10","conditions":"Amputation, Phantom Limb, Stump Pain","enrollment":7},{"nctId":"NCT01234272","phase":"PHASE4","title":"Comparison of the Analgesic Effect Between Intrathecal Morphine and IV-fentanyl Patient Controlled Analgesia (ITM-IVPCA) and Epidural PCA (PCEA) in Patients Undergoing Gastrectomy -Randomized Allocation Study-","status":"COMPLETED","sponsor":"Yonsei University","startDate":"2010-08","conditions":"Gastric Cancer","enrollment":59},{"nctId":"NCT00987441","phase":"NA","title":"Epidural Labor Analgesia and Infant Neurobehavior","status":"COMPLETED","sponsor":"Nanjing Medical University","startDate":"2009-09","conditions":"Labor Pain","enrollment":1200},{"nctId":"NCT00702416","phase":"PHASE4","title":"Ultrasound Guidance for Interscalene Brachial Plexus Block","status":"COMPLETED","sponsor":"University of Parma","startDate":"2008-05","conditions":"Shoulder, Orthopedic Surgery, Nerve Block","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["continuous peripheral nerve block"],"phase":"marketed","status":"active","brandName":"Ropivacaine 0.4%","genericName":"Ropivacaine 0.4%","companyName":"University of California, San Diego","companyId":"university-of-california-san-diego","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local and regional anesthesia for surgery and acute pain management, Peripheral nerve blocks, Epidural anesthesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}