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Ropivacaïne
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. Used for Local and regional anesthesia for surgery and acute pain management, Peripheral nerve blocks, Epidural and spinal anesthesia.
At a glance
| Generic name | Ropivacaïne |
|---|---|
| Sponsor | Nantes University Hospital |
| Drug class | Local anesthetic (amide) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia / Pain Management |
| Phase | FDA-approved |
Mechanism of action
Ropivacaine reversibly inhibits sodium influx through voltage-gated sodium channels in nerve fibers, thereby stabilizing the neuronal membrane and preventing depolarization. This action blocks the conduction of nerve impulses in sensory, motor, and autonomic fibers depending on the concentration and route of administration. It is an amide-type local anesthetic with a long duration of action and relatively low systemic toxicity compared to some alternatives.
Approved indications
- Local and regional anesthesia for surgery and acute pain management
- Peripheral nerve blocks
- Epidural and spinal anesthesia
Common side effects
- Hypotension
- Bradycardia
- Nausea
- Dizziness
- Systemic toxicity (CNS and cardiac effects at high doses)
Key clinical trials
- Analgesic Effect of the QLB-3 for Patients Undergoing a Total Hip Surgery (NA)
- Effects of Insufflated Gas on Core Temperature and Post-operative Pain During Laparoscopic Surgery (NA)
- Comparative Study of the Effects of Two Local Anesthetics Administered Intrathecally: 0.5% Levobupivacaine and Ropivacaine 0.5% (PHASE4)
- Study of the Analgesic Effect of the Perineal Infiltration of Ropivacaine 0.75% Versus Placebo in Post-episiotomy Perineal Pain (PHASE3)
- Chlorhydrate of Ropivacaine and Breast Cancer Surgery (PHASE4)
- ER-One: A Double-blind Trial of Erector Spinae Block (ESP) Versus Paravertebral Block (PVB) Before Breast Cancer Surgery (PHASE4)
- MIRs 04 : Interpectoral Nerve Block With Ropivacaine Versus Placebo Before Breast Cancer Surgery (PHASE3)
- Evaluation of Perineural Catheterization Practices in Postoperative Orthopedic Surgery
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ropivacaïne CI brief — competitive landscape report
- Ropivacaïne updates RSS · CI watch RSS
- Nantes University Hospital portfolio CI