{"id":"ropivaca-ne","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Systemic toxicity (CNS and cardiac effects at high doses)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ropivacaine reversibly inhibits sodium influx through voltage-gated sodium channels in nerve fibers, thereby stabilizing the neuronal membrane and preventing depolarization. This action blocks the conduction of nerve impulses in sensory, motor, and autonomic fibers depending on the concentration and route of administration. It is an amide-type local anesthetic with a long duration of action and relatively low systemic toxicity compared to some alternatives.","oneSentence":"Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:05:40.815Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local and regional anesthesia for surgery and acute pain management"},{"name":"Peripheral nerve blocks"},{"name":"Epidural and spinal anesthesia"}]},"trialDetails":[{"nctId":"NCT04555291","phase":"NA","title":"Analgesic Effect of the QLB-3 for Patients Undergoing a Total Hip Surgery","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire de Nice","startDate":"2022-01-05","conditions":"Total Hip Arthroplasty","enrollment":60},{"nctId":"NCT00372268","phase":"NA","title":"Effects of Insufflated Gas on Core Temperature and 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Used for Local and regional anesthesia for surgery and acute pain management, Peripheral nerve blocks, Epidural and spinal anesthesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}