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Root Canal Sealants
Root canal sealants are biocompatible materials that fill and seal the root canal system after pulp removal to prevent bacterial recontamination and promote healing.
Root canal sealants are biocompatible materials that fill and seal the root canal system after pulp removal to prevent bacterial recontamination and promote healing. Used for Root canal obturation and sealing following pulp removal in endodontic therapy.
At a glance
| Generic name | Root Canal Sealants |
|---|---|
| Sponsor | Yuzuncu Yil University |
| Modality | Small molecule |
| Therapeutic area | Dentistry/Endodontics |
| Phase | FDA-approved |
Mechanism of action
Root canal sealants work by creating an impermeable barrier within the root canal space, sealing lateral canals and apical foramina to prevent ingress of oral bacteria and tissue fluids. They are typically used in conjunction with gutta-percha or other core filling materials as part of endodontic therapy. The sealant adheres to dentin walls and the core material, providing a three-dimensional seal that enhances treatment success rates.
Approved indications
- Root canal obturation and sealing following pulp removal in endodontic therapy
Common side effects
- Periapical inflammation or exacerbation
- Allergic reaction to sealant components
- Cytotoxicity to periapical tissues
Key clinical trials
- Mineral Trioxide Aggregate (MTA) vs Gutta-Percha for Non-Surgical Endodontic Retreatment in Teeth With Apical Lesions (NA)
- Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment (NA)
- Clinical Efficacy of AH Plus Bioceramic Sealer (NA)
- Post Operative Sensitivity of MTA Obturation
- Post-Endodontic Pain According to Menstrual Cycle Phases
- Zinc Oxide-Ozonated Olive Oil vs Metapex in Primary Anterior Teeth (NA)
- Pulpotomy With CEM vs Pulpectomy With Ca(OH)2/Iodoform in Primary Molars (NA)
- Comparison of Leakage in Endodontically Treated Teeth Obturated With Different Types of Gutta Percha Coatings and Bioceramic Sealer (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Root Canal Sealants CI brief — competitive landscape report
- Root Canal Sealants updates RSS · CI watch RSS
- Yuzuncu Yil University portfolio CI