{"id":"root-canal-sealants","safety":{"commonSideEffects":[{"rate":null,"effect":"Periapical inflammation or exacerbation"},{"rate":null,"effect":"Allergic reaction to sealant components"},{"rate":null,"effect":"Cytotoxicity to periapical tissues"}]},"_chembl":{"chemblId":"CHEMBL1201531","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Root canal sealants work by creating an impermeable barrier within the root canal space, sealing lateral canals and apical foramina to prevent ingress of oral bacteria and tissue fluids. They are typically used in conjunction with gutta-percha or other core filling materials as part of endodontic therapy. The sealant adheres to dentin walls and the core material, providing a three-dimensional seal that enhances treatment success rates.","oneSentence":"Root canal sealants are biocompatible materials that fill and seal the root canal system after pulp removal to prevent bacterial recontamination and promote healing.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:05:37.651Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Root canal obturation and sealing following pulp removal in endodontic therapy"}]},"trialDetails":[{"nctId":"NCT07477171","phase":"NA","title":"Mineral Trioxide Aggregate (MTA) vs Gutta-Percha for Non-Surgical Endodontic Retreatment in Teeth With Apical Lesions","status":"NOT_YET_RECRUITING","sponsor":"University of Santiago de Compostela","startDate":"2026-03","conditions":"Periapical Diseases, Root Canal Therapy, Mineral Trioxide Aggregate (MTA)","enrollment":58},{"nctId":"NCT07448571","phase":"NA","title":"Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment","status":"RECRUITING","sponsor":"Marmara University","startDate":"2025-05-01","conditions":"Apical Periodontitis, Periapical Diseases","enrollment":140},{"nctId":"NCT05763420","phase":"NA","title":"Clinical Efficacy of AH Plus Bioceramic Sealer","status":"ENROLLING_BY_INVITATION","sponsor":"Ministry of Health, Kuwait","startDate":"2023-08-07","conditions":"Root Canal Infection, Periapical Periodontitis, Periapical Diseases","enrollment":136},{"nctId":"NCT06795282","phase":"","title":"Post Operative Sensitivity of MTA Obturation","status":"COMPLETED","sponsor":"TC Erciyes University","startDate":"2025-01-30","conditions":"Dental Pulp Disease, Endodontically Treated Teeth, Endodontic Disease","enrollment":54},{"nctId":"NCT07291518","phase":"","title":"Post-Endodontic Pain According to Menstrual Cycle Phases","status":"COMPLETED","sponsor":"Ahter Sanal Cikman","startDate":"2023-09-01","conditions":"Root Canal Treatment","enrollment":99},{"nctId":"NCT07265089","phase":"NA","title":"Zinc Oxide-Ozonated Olive Oil vs Metapex in Primary Anterior Teeth","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-12-01","conditions":"Carious Anterior Teeth","enrollment":52},{"nctId":"NCT07265063","phase":"NA","title":"Pulpotomy With CEM vs Pulpectomy With Ca(OH)2/Iodoform in Primary Molars","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-12-01","conditions":"Carious Primary Molars","enrollment":50},{"nctId":"NCT07205809","phase":"NA","title":"Comparison of Leakage in Endodontically Treated Teeth Obturated With Different Types of Gutta Percha Coatings and Bioceramic Sealer","status":"NOT_YET_RECRUITING","sponsor":"Pakistan Institute of Medical Sciences","startDate":"2025-11-05","conditions":"Leakage Testing","enrollment":60},{"nctId":"NCT07206108","phase":"NA","title":"Clinical Trial of Modified Endocrown and Personalized Post-core and Crown for Large-area Tooth Defects After Root Canal Treatment","status":"RECRUITING","sponsor":"Nanfang Hospital, Southern Medical University","startDate":"2025-08-04","conditions":"Root Canal Infection, Tooth Defect, Post and Core Technique","enrollment":246},{"nctId":"NCT06798467","phase":"NA","title":"Evaluation of Post Obturation Pain Associated With Calcium Hydroxide-based Root Canal Sealers and Resin-based Root Canal Sealer: a Single Visit Root Canal Treatment","status":"COMPLETED","sponsor":"Jinnah Sindh Medical University","startDate":"2024-10-01","conditions":"Root Canal Sealers, Post Operative Pain, Irreversible Pulpitis","enrollment":60},{"nctId":"NCT03839485","phase":"PHASE3","title":"Endodontic Treatment of Primary Teeth With Guedes-Pinto Paste Without Antibiotic","status":"COMPLETED","sponsor":"University of Sao Paulo","startDate":"2018-06-08","conditions":"Pulp Disorder","enrollment":100},{"nctId":"NCT06755502","phase":"NA","title":"Garlic Oil As Root Filling Material in Primary Molars","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-08-08","conditions":"Irreversible Pulpitis (toothache)","enrollment":40},{"nctId":"NCT06860191","phase":"PHASE4","title":"Effect of Different Sealers and Activation Methods on Pain","status":"NOT_YET_RECRUITING","sponsor":"TC Erciyes University","startDate":"2025-03-01","conditions":"Chronic Apical Periodontitis","enrollment":80},{"nctId":"NCT06597825","phase":"NA","title":"Antibacterial Effect of NaOCl With Etidronic Acid in Apical Periodontitis Treatment","status":"COMPLETED","sponsor":"Mustafa Kemal University","startDate":"2020-08-17","conditions":"Healthy","enrollment":40},{"nctId":"NCT06518304","phase":"NA","title":"Effectiveness of GentleWave System in Endodontic Treatment","status":"NOT_YET_RECRUITING","sponsor":"University of Salamanca","startDate":"2024-08-20","conditions":"Pain, Postoperative, Root Canal Infection, Endodontically Treated Teeth","enrollment":70},{"nctId":"NCT06482593","phase":"PHASE4","title":"Periapical Healing in Response to Endodontically Treated Teeth With Different Sealing Cement","status":"ACTIVE_NOT_RECRUITING","sponsor":"Institucion Universitaria Colegios de Colombia","startDate":"2023-08-01","conditions":"Apical Periodontitis","enrollment":72},{"nctId":"NCT05633537","phase":"NA","title":"Clinical & Radiographic Evaluation of Zinc Oxide-Ozonated Oil as a New Primary Root Canal Filling","status":"COMPLETED","sponsor":"Tanta University","startDate":"2021-07-04","conditions":"Pulp Disease, Dental, Obturation, Root Canal Infection","enrollment":90},{"nctId":"NCT05816772","phase":"EARLY_PHASE1","title":"Comparison of Post-Operative Pain After Use of Calcium Hydroxide and Bio Ceramic Sealer for Root Canal Treatment.","status":"COMPLETED","sponsor":"Dow University of Health Sciences","startDate":"2022-10-25","conditions":"Postoperative Pain","enrollment":80},{"nctId":"NCT05305417","phase":"NA","title":"Cell-free Autologous Regenerative Endodontics Treatment for Teeth With Periapical Lesions (CARETT)","status":"UNKNOWN","sponsor":"Universidad de Valparaiso","startDate":"2023-03","conditions":"Periapical Diseases, Pulp Necroses","enrollment":228},{"nctId":"NCT05230797","phase":"EARLY_PHASE1","title":"Zincoxide-propolis vs Zincoxide-eugenol Pulpectomy","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2022-04","conditions":"Pulp Necroses","enrollment":38},{"nctId":"NCT05039502","phase":"NA","title":"Releasing of Inflammatory Mediators During Retreatment of Root Canals","status":"COMPLETED","sponsor":"Bulent Ecevit University","startDate":"2020-10-01","conditions":"Inflammatory Response, Root Canal Infection","enrollment":75},{"nctId":"NCT05033093","phase":"NA","title":"Effect of Resin, Calcium Silicate and Silicone Based Root Canal Sealers on Postoperative Pain","status":"UNKNOWN","sponsor":"Yuzuncu Yil University","startDate":"2021-09-01","conditions":"Postoperative Pain","enrollment":84},{"nctId":"NCT02573090","phase":"NA","title":"Sealing Manifest Occlusal Caries Lesions in the Permanent Dentition","status":"COMPLETED","sponsor":"University of Copenhagen","startDate":"2006-11","conditions":"Dental Caries","enrollment":521},{"nctId":"NCT04338854","phase":"NA","title":"Dental Anxiety in Children and Salivary Cortisol Levels","status":"COMPLETED","sponsor":"Inonu University","startDate":"2017-12-15","conditions":"Dental Anxiety","enrollment":135},{"nctId":"NCT03684915","phase":"NA","title":"Clinical Post-operative Assessment of Chronic Signs & Symptoms Related to Infected Primary Molars After Using Rotary Versus Manual Systems in Cleaning the Root Canals","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2018-10-01","conditions":"Chronic Infection","enrollment":50},{"nctId":"NCT03514264","phase":"NA","title":"Clinical Applicability of PBSCIMMO as a Single Material in Endodontic Obturations","status":"UNKNOWN","sponsor":"Universidade do Vale do Sapucai","startDate":"2017-11-09","conditions":"Root Canal Therapy","enrollment":70},{"nctId":"NCT03074136","phase":"PHASE2","title":"Application of Photodynamic Therapy and Diode Laser for Endodontic Therapy of Young Permanent Teeth","status":"COMPLETED","sponsor":"Association of Paediatric and Preventive Dentists of Serbia","startDate":"2017-02-10","conditions":"Teeth, Endodontically-Treated","enrollment":45},{"nctId":"NCT02905773","phase":"EARLY_PHASE1","title":"Postoperative Pain After the Removal of Root Canal Filling Material","status":"COMPLETED","sponsor":"TC Erciyes University","startDate":"2015-03","conditions":"Postoperative Pain","enrollment":135}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":27,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Root Canal Sealants","genericName":"Root Canal Sealants","companyName":"Yuzuncu Yil University","companyId":"yuzuncu-yil-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Root canal sealants are used in conjunction with root canal treatment to prevent conditions such as dental caries, chronic infection, and pulp necroses. The mechanism of root canal sealants is currently unknown, but they are often used in combination with non-invasive resin-based fissure sealing or invasive resin-based restorations.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}