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Rifampicin, Pyrazinamide, Ethambutol and Isoniazid
Rifampicin, Pyrazinamide, Ethambutol and Isoniazid is a Anti-tuberculosis agent (fixed-dose combination) Small molecule drug developed by University of Cape Town. It is currently in Phase 3 development for Tuberculosis (drug-susceptible, pulmonary and extrapulmonary). Also known as: Rifafour.
This is a fixed-dose combination of four first-line anti-tuberculosis drugs that work synergistically to inhibit bacterial cell wall synthesis and protein production, killing Mycobacterium tuberculosis.
This is a fixed-dose combination of four first-line anti-tuberculosis drugs that work synergistically to inhibit bacterial cell wall synthesis and protein production, killing Mycobacterium tuberculosis. Used for Tuberculosis (drug-susceptible, pulmonary and extrapulmonary).
At a glance
| Generic name | Rifampicin, Pyrazinamide, Ethambutol and Isoniazid |
|---|---|
| Also known as | Rifafour |
| Sponsor | University of Cape Town |
| Drug class | Anti-tuberculosis agent (fixed-dose combination) |
| Target | Bacterial RNA polymerase (rifampicin), mycolic acid synthesis (isoniazid), cellular metabolism (pyrazinamide), arabinosyl transferase (ethambutol) |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | Phase 3 |
Mechanism of action
Rifampicin inhibits bacterial RNA polymerase, isoniazid inhibits mycolic acid synthesis in the cell wall, pyrazinamide disrupts cellular metabolism and energy production, and ethambutol inhibits arabinosyl transferases involved in cell wall synthesis. Together, these agents target multiple pathways to prevent resistance and achieve rapid bactericidal activity against tuberculosis.
Approved indications
- Tuberculosis (drug-susceptible, pulmonary and extrapulmonary)
Common side effects
- Hepatotoxicity
- Peripheral neuropathy
- Hyperuricemia
- Optic neuritis (ethambutol-related)
- Gastrointestinal disturbance
- Rash
- Arthralgia
Key clinical trials
- Safety and Tolerability of Metformin in People With Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) (PHASE2)
- Trial of Novel Regimens for the Treatment of Pulmonary Tuberculosis (PHASE2)
- AIPH-TB: AI-Optimised Pyrazinamide-Hydroxychloroquine vs Standard RIPE for Drug-Sensitive Pulmonary Tuberculosis - A Phase II RCT (PHASE2)
- Phase 2a Trial of Alpibectir Plus Ethionamide for Tuberculosis Meningitis (PHASE2)
- Digitally Facilitated, Integrated Community and Facility-Based Interventions: The HEART-TB Trial Protocol (NA)
- Ultra-Short Course Bedaquiline, Clofazimine, Pyrazinamide and Delamanid Versus Standard Therapy for Drug-Susceptible TB (PHASE2)
- Asymptomatic TB With Innovative Modified Short-course Regimens (PHASE4)
- ATORvastatin in Pulmonary TUBerculosis: a POPulation PharmacoKinetics -PharmacoDynamics Sub-study (ATORTUB popPK-PD) (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Rifampicin, Pyrazinamide, Ethambutol and Isoniazid CI brief — competitive landscape report
- Rifampicin, Pyrazinamide, Ethambutol and Isoniazid updates RSS · CI watch RSS
- University of Cape Town portfolio CI
Frequently asked questions about Rifampicin, Pyrazinamide, Ethambutol and Isoniazid
What is Rifampicin, Pyrazinamide, Ethambutol and Isoniazid?
How does Rifampicin, Pyrazinamide, Ethambutol and Isoniazid work?
What is Rifampicin, Pyrazinamide, Ethambutol and Isoniazid used for?
Who makes Rifampicin, Pyrazinamide, Ethambutol and Isoniazid?
Is Rifampicin, Pyrazinamide, Ethambutol and Isoniazid also known as anything else?
What drug class is Rifampicin, Pyrazinamide, Ethambutol and Isoniazid in?
What development phase is Rifampicin, Pyrazinamide, Ethambutol and Isoniazid in?
What are the side effects of Rifampicin, Pyrazinamide, Ethambutol and Isoniazid?
What does Rifampicin, Pyrazinamide, Ethambutol and Isoniazid target?
Related
- Drug class: All Anti-tuberculosis agent (fixed-dose combination) drugs
- Target: All drugs targeting Bacterial RNA polymerase (rifampicin), mycolic acid synthesis (isoniazid), cellular metabolism (pyrazinamide), arabinosyl transferase (ethambutol)
- Manufacturer: University of Cape Town — full pipeline
- Therapeutic area: All drugs in Infectious Disease
- Indication: Drugs for Tuberculosis (drug-susceptible, pulmonary and extrapulmonary)
- Also known as: Rifafour