Who are Rifampicin, Pyrazinamide, Ethambutol and Isoniazid's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Rifampin, isoniazid, pyrazinamide, ethambutol, Rifampin/isoniazid/pyrazinamide/ethambutol FDC, HR.

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Last reviewed 2026-05-18 · How we verify

Rifampicin, Pyrazinamide, Ethambutol and Isoniazid — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Rifampicin, Pyrazinamide, Ethambutol and Isoniazid (Rifampicin, Pyrazinamide, Ethambutol and Isoniazid) competitive landscape: 3 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Anti-tuberculosis agent (fixed-dose combination). Area: Infectious Disease.

phase 3 Anti-tuberculosis agent (fixed-dose combination) Bacterial RNA polymerase (rifampicin), mycolic acid synthesis (isoniazid), cellular metabolism (pyrazinamide), arabinosyl transferase (ethambutol) Infectious Disease Small molecule Live · refreshed every 30 min

Target snapshot

Rifampicin, Pyrazinamide, Ethambutol and Isoniazid (Rifampicin, Pyrazinamide, Ethambutol and Isoniazid) — University of Cape Town. This is a fixed-dose combination of four first-line anti-tuberculosis drugs that work synergistically to inhibit bacterial cell wall synthesis and protein production, killing Mycobacterium tuberculosis.

Comparator set (3 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Rifampicin, Pyrazinamide, Ethambutol and Isoniazid TARGET	Rifampicin, Pyrazinamide, Ethambutol and Isoniazid	University of Cape Town	phase 3	Anti-tuberculosis agent (fixed-dose combination)	Bacterial RNA polymerase (rifampicin), mycolic acid synthesis (isoniazid), cellular metabolism (pyrazinamide), arabinosyl transferase (ethambutol)
Rifampin, isoniazid, pyrazinamide, ethambutol	Rifampin, isoniazid, pyrazinamide, ethambutol	ANRS, Emerging Infectious Diseases	marketed	Anti-tuberculosis agent (fixed-dose combination)	Multiple: RNA polymerase (rifampin), mycolic acid synthesis (isoniazid), arabinosyl transferases (ethambutol), pyrazinamidase/nicotinamidase (pyrazinamide)
Rifampin/isoniazid/pyrazinamide/ethambutol FDC	Rifampin/isoniazid/pyrazinamide/ethambutol FDC	Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections	marketed	Anti-tuberculosis agent (fixed-dose combination)	Bacterial RNA polymerase (rifampin), mycolic acid synthesis (isoniazid), membrane potential/energy metabolism (pyrazinamide), arabinosyl transferase (ethambutol)
HR	HR	Global Alliance for TB Drug Development	marketed	Anti-tuberculosis agent (fixed-dose combination)	Mycobacterial cell wall (isoniazid) and bacterial RNA polymerase (rifampicin)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Anti-tuberculosis agent (fixed-dose combination) class)

ANRS, Emerging Infectious Diseases · 1 drug in this class
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections · 1 drug in this class
Global Alliance for TB Drug Development · 1 drug in this class
University of Cape Town · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Rifampicin, Pyrazinamide, Ethambutol and Isoniazid — Competitive Intelligence Brief. https://druglandscape.com/ci/rifampicin-pyrazinamide-ethambutol-and-isoniazid. Accessed 2026-05-18.

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