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Rheum Palmatum Root
Rheum palmatum root acts as a natural laxative and anti-inflammatory agent, primarily through its anthraquinone content which stimulates intestinal motility and promotes bowel evacuation.
Rheum palmatum root acts as a natural laxative and anti-inflammatory agent, primarily through its anthraquinone content which stimulates intestinal motility and promotes bowel evacuation. Used for Constipation, Digestive disorders (traditional use).
At a glance
| Generic name | Rheum Palmatum Root |
|---|---|
| Also known as | Chinese Rhubarb Root |
| Sponsor | CHEN De-chang |
| Drug class | Herbal laxative / Natural remedy |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
The root contains active compounds including emodin, rhein, and other anthraquinones that irritate the colon mucosa, triggering peristalsis and increasing stool bulk. Additionally, the plant exhibits hepatoprotective and anti-inflammatory properties through polyphenolic compounds, making it useful in traditional medicine for digestive and inflammatory conditions.
Approved indications
- Constipation
- Digestive disorders (traditional use)
Common side effects
- Abdominal cramping
- Diarrhea
- Electrolyte imbalance (with chronic use)
Key clinical trials
- Yiwei Jiaohuang Ointment for Gastrointestinal Bleeding Associated With Oral Antithrombotic Agents (EARLY_PHASE1)
- The Beneficial Effect of TJ-134 for Patients With Symptomatic Pneumatosis Cystoides Intestinalis (NA)
- Combining Chinese Medicine and Nutrition to Enhance Weight Loss After Bariatric Surgery (NA)
- Clinical Study on the Treatment of Diabetic Kidney Disease With Shenxiao Yuning Decoction With Syndrome of Qi and Yin Deficiency and Blood Stasis (NA)
- Gut Microbiome and Blood Markers After Habitual Herbal Tea Consumption (EARLY_PHASE1)
- The Effect of Rhubarb on Sepsis and Post-traumatic Gastrointestinal Function Failure (PHASE2)
- Fu-zheng-qu-zhuo Oral Liquid Improves Renal Function in Patients of CKD Stage 3 and 4 (PHASE2)
- The Evaluation Studies of Curative Effect of Fu-zheng-qu-zhuo Oral Liquid in Treatment of Ischemic Nephropathy (PHASE2, PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Rheum Palmatum Root CI brief — competitive landscape report
- Rheum Palmatum Root updates RSS · CI watch RSS
- CHEN De-chang portfolio CI