{"id":"rheum-palmatum-root","safety":{"commonSideEffects":[{"rate":null,"effect":"Abdominal cramping"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Electrolyte imbalance (with chronic use)"}]},"_chembl":{"chemblId":"CHEMBL1201531","moleculeType":"Unknown"},"_dailymed":{"setId":"7fc6fed4-6604-43ca-8850-1a594b64eaa5","title":"NEURORESCUEX HH333 (SCUTELLARIA BAICALENSIS ROOT, COPTIS JAPONICA ROOT, PHELLODENDRON CHINENSIS BARK, GARDENIA JASMINOIDES FRUIT, RHEUM PALMATUM ROOT) CAPSULE [PANACURA INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The root contains active compounds including emodin, rhein, and other anthraquinones that irritate the colon mucosa, triggering peristalsis and increasing stool bulk. Additionally, the plant exhibits hepatoprotective and anti-inflammatory properties through polyphenolic compounds, making it useful in traditional medicine for digestive and inflammatory conditions.","oneSentence":"Rheum palmatum root acts as a natural laxative and anti-inflammatory agent, primarily through its anthraquinone content which stimulates intestinal motility and promotes bowel evacuation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T03:45:36.908Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Constipation"},{"name":"Digestive disorders (traditional use)"}]},"trialDetails":[{"nctId":"NCT07339956","phase":"EARLY_PHASE1","title":"Yiwei Jiaohuang Ointment for Gastrointestinal Bleeding Associated With Oral Antithrombotic Agents","status":"NOT_YET_RECRUITING","sponsor":"China-Japan Friendship Hospital","startDate":"2026-01-10","conditions":"Gastrointestinal Bleeding","enrollment":60},{"nctId":"NCT04368663","phase":"NA","title":"The Beneficial Effect of TJ-134 for Patients With Symptomatic Pneumatosis Cystoides Intestinalis","status":"RECRUITING","sponsor":"Showa Inan General Hospital","startDate":"2020-05-01","conditions":"Pneumatosis Cystoides Intestinalis","enrollment":100},{"nctId":"NCT06419764","phase":"NA","title":"Combining Chinese Medicine and Nutrition to Enhance Weight Loss After Bariatric Surgery","status":"RECRUITING","sponsor":"China-Japan Friendship Hospital","startDate":"2024-02-01","conditions":"Traditional Chinese Medicine Treatment, Weight Change","enrollment":120},{"nctId":"NCT06176599","phase":"NA","title":"Clinical Study on the Treatment of Diabetic Kidney Disease With Shenxiao Yuning Decoction With Syndrome of Qi and Yin Deficiency and Blood Stasis","status":"UNKNOWN","sponsor":"Lin Liao","startDate":"2022-09-01","conditions":"Diabetic Kidney Disease","enrollment":60},{"nctId":"NCT05862532","phase":"EARLY_PHASE1","title":"Gut Microbiome and Blood Markers After Habitual Herbal Tea Consumption","status":"UNKNOWN","sponsor":"Aberystwyth University","startDate":"2022-11-17","conditions":"Obesity, Well-being","enrollment":55},{"nctId":"NCT03048903","phase":"PHASE2","title":"The Effect of Rhubarb on Sepsis and Post-traumatic Gastrointestinal Function Failure","status":"UNKNOWN","sponsor":"CHEN De-chang","startDate":"2016-02","conditions":"Sepsis","enrollment":400},{"nctId":"NCT02275468","phase":"PHASE2","title":"Fu-zheng-qu-zhuo Oral Liquid Improves Renal Function in Patients of CKD Stage 3 and 4","status":"COMPLETED","sponsor":"Guang'anmen Hospital of China Academy of Chinese Medical Sciences","startDate":"2010-06","conditions":"Stage 3 Chronic Kidney Disease, Stage 4 Chronic Kidney Disease","enrollment":124},{"nctId":"NCT02044835","phase":"PHASE2, PHASE3","title":"The Evaluation Studies of Curative Effect of Fu-zheng-qu-zhuo Oral Liquid in Treatment of Ischemic Nephropathy","status":"UNKNOWN","sponsor":"Guang'anmen Hospital of China Academy of Chinese Medical Sciences","startDate":"2013-01","conditions":"Atherosclerotic Renal Artery Stenosis","enrollment":60},{"nctId":"NCT00569088","phase":"PHASE2","title":"Study of the Pathogenesis and Molecular Mechanism of \"YURE\" in Internal Intractable Diseases","status":"UNKNOWN","sponsor":"Nanjing University of Traditional Chinese Medicine","startDate":"2007-11","conditions":"Stroke","enrollment":300}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"CONDITION AGGRAVATED"},{"count":1,"reaction":"VANISHING BILE DUCT SYNDROME"}],"_approvalHistory":[],"publicationCount":12,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Chinese Rhubarb Root"],"phase":"marketed","status":"active","brandName":"Rheum Palmatum Root","genericName":"Rheum Palmatum Root","companyName":"CHEN De-chang","companyId":"chen-de-chang","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Rheum palmatum root acts as a natural laxative and anti-inflammatory agent, primarily through its anthraquinone content which stimulates intestinal motility and promotes bowel evacuation. Used for Constipation, Digestive disorders (traditional use).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}