Last reviewed · How we verify
Remimazolam besylate + propofol MCT
Remimazolam besylate + propofol MCT is a Benzodiazepine + propofol combination sedative-hypnotic Small molecule drug developed by Chung-Ang University Gwangmyeong Hospital. It is currently FDA-approved for Procedural sedation and anesthesia.
Remimazolam besylate is a benzodiazepine that enhances GABAergic inhibition in the central nervous system, while propofol MCT is a lipophilic sedative-hypnotic that potentiates GABA receptor activity; together they provide rapid-onset, short-acting sedation and anesthesia.
Remimazolam besylate is a benzodiazepine that enhances GABAergic inhibition in the central nervous system, while propofol MCT is a lipophilic sedative-hypnotic that potentiates GABA receptor activity; together they provide rapid-onset, short-acting sedation and anesthesia. Used for Procedural sedation and anesthesia.
At a glance
| Generic name | Remimazolam besylate + propofol MCT |
|---|---|
| Sponsor | Chung-Ang University Gwangmyeong Hospital |
| Drug class | Benzodiazepine + propofol combination sedative-hypnotic |
| Target | GABA-A receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Sedation |
| Phase | FDA-approved |
Mechanism of action
Remimazolam is a rapid-onset, short-acting benzodiazepine agonist at GABA-A receptors that is metabolized by esterases, allowing quick reversal with flumazenil if needed. Propofol MCT (medium-chain triglyceride formulation) is an intravenous hypnotic that acts as a positive allosteric modulator of GABA-A receptors. The combination provides synergistic sedative and anesthetic effects for procedural sedation.
Approved indications
- Procedural sedation and anesthesia
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Injection site pain
Key clinical trials
- A Comparison of Remimazolam Besylate and Propofol Sedation in Patients Undergoing Colonoscopic Polypectomy (PHASE4)
- A Randomized, Controlled Clinical Trial Comparing Remimazolam Besylate Combined With Alfentanil Versus Propofol Combined With Alfentanil for Anesthesia in Thoracic Surgery (PHASE4)
- Sedation Efficacy and Safety of Remazolam Besylate in Ventilated Surgical Critically Ill Patients (PHASE4)
- Remimazolam vs Propofol in Laser Burn Cases (PHASE4)
- Remimazolam vs. Midazolam for Sedation and Cognitive Outcomes in Orthopedic Surgery (PHASE3)
- Remimazolam Infusion in Kidney Transplant Patients: A Multicenter Study (PHASE1)
- Comparison of Hemodynamic Stability During Anesthesia Using Remimazolam and Sevoflurane in Minimally Invasive AVR (NA)
- Total Intravenous Anesthesia for Rigid Bronchoscopy Using Remimazolam (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Remimazolam besylate + propofol MCT CI brief — competitive landscape report
- Remimazolam besylate + propofol MCT updates RSS · CI watch RSS
- Chung-Ang University Gwangmyeong Hospital portfolio CI
Frequently asked questions about Remimazolam besylate + propofol MCT
What is Remimazolam besylate + propofol MCT?
How does Remimazolam besylate + propofol MCT work?
What is Remimazolam besylate + propofol MCT used for?
Who makes Remimazolam besylate + propofol MCT?
What drug class is Remimazolam besylate + propofol MCT in?
What development phase is Remimazolam besylate + propofol MCT in?
What are the side effects of Remimazolam besylate + propofol MCT?
What does Remimazolam besylate + propofol MCT target?
Related
- Drug class: All Benzodiazepine + propofol combination sedative-hypnotic drugs
- Target: All drugs targeting GABA-A receptor
- Manufacturer: Chung-Ang University Gwangmyeong Hospital — full pipeline
- Therapeutic area: All drugs in Anesthesia/Sedation
- Indication: Drugs for Procedural sedation and anesthesia
- Compare: Remimazolam besylate + propofol MCT vs similar drugs
- Pricing: Remimazolam besylate + propofol MCT cost, discount & access