{"id":"remimazolam-besylate-propofol-mct","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Injection site pain"}]},"_chembl":{"chemblId":"CHEMBL4594301","moleculeType":"Small molecule","molecularWeight":"597.49"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Remimazolam is a rapid-onset, short-acting benzodiazepine agonist at GABA-A receptors that is metabolized by esterases, allowing quick reversal with flumazenil if needed. Propofol MCT (medium-chain triglyceride formulation) is an intravenous hypnotic that acts as a positive allosteric modulator of GABA-A receptors. The combination provides synergistic sedative and anesthetic effects for procedural sedation.","oneSentence":"Remimazolam besylate is a benzodiazepine that enhances GABAergic inhibition in the central nervous system, while propofol MCT is a lipophilic sedative-hypnotic that potentiates GABA receptor activity; together they provide rapid-onset, short-acting sedation and anesthesia.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:04:32.248Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Procedural sedation and anesthesia"}]},"trialDetails":[{"nctId":"NCT07456111","phase":"PHASE4","title":"A Comparison of Remimazolam Besylate and Propofol Sedation in Patients Undergoing Colonoscopic Polypectomy","status":"RECRUITING","sponsor":"Clinical Hospital Centre Zagreb","startDate":"2025-01-01","conditions":"Colonic Polyp, Sedation Complication","enrollment":90},{"nctId":"NCT07347496","phase":"PHASE4","title":"A Randomized, Controlled Clinical Trial 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