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regional anesthesia and PAI
Regional anesthesia combined with plasminogen activator inhibitor (PAI) modulation reduces pain and inflammation at the injection site while potentially modulating fibrinolytic activity.
Regional anesthesia combined with plasminogen activator inhibitor (PAI) modulation reduces pain and inflammation at the injection site while potentially modulating fibrinolytic activity. Used for Postoperative pain management, Regional anesthesia adjunct.
At a glance
| Generic name | regional anesthesia and PAI |
|---|---|
| Also known as | adductor canal block, periarticular injection |
| Sponsor | Washington University School of Medicine |
| Modality | Small molecule |
| Therapeutic area | Anesthesia / Pain Management |
| Phase | FDA-approved |
Mechanism of action
This appears to be a combination approach using regional anesthetic techniques (local nerve blocks or infiltration) paired with PAI (plasminogen activator inhibitor) to manage postoperative pain and potentially reduce bleeding or thrombotic complications. The regional anesthetic component blocks nerve conduction locally, while PAI modulation may influence fibrinolysis and hemostasis in the surgical field.
Approved indications
- Postoperative pain management
- Regional anesthesia adjunct
Common side effects
- Local anesthetic toxicity
- Nerve injury
- Hematoma
Key clinical trials
- PENG Block vs PENG Plus Periarticular Injection vs Periarticular Injection in Older Adults (NA)
- iPACK Block vs. Periarticular Infiltration for TKA Pain Control (NA)
- Block and Periarticular Injection Study (PHASE4)
- Effects of Bioflavanoids on Vascular Wall Remodeling in Patients With Varicose Veins (NA)
- Impact of Adductor Canal Block on Functional Recovery (NA)
- Erector Spinae Block Versus Shoulder Periarticular Anesthetic Infiltration for Arthroscopic Shoulder Surgery (NA)
- Efficacy of Ipack Block and Surgeon's Joint Infiltration in Total Knee Arthroplasty (PHASE4)
- Peripheral Nerve Blocks vs Periarticular Local Anesthetic Injection for Total Knee Arthroplasty (TKA) (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- regional anesthesia and PAI CI brief — competitive landscape report
- regional anesthesia and PAI updates RSS · CI watch RSS
- Washington University School of Medicine portfolio CI