{"id":"regional-anesthesia-and-pai","safety":{"commonSideEffects":[{"rate":null,"effect":"Local anesthetic toxicity"},{"rate":null,"effect":"Nerve injury"},{"rate":null,"effect":"Hematoma"}]},"_chembl":{"chemblId":"CHEMBL1255654","moleculeType":"Small molecule","molecularWeight":"300.83"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This appears to be a combination approach using regional anesthetic techniques (local nerve blocks or infiltration) paired with PAI (plasminogen activator inhibitor) to manage postoperative pain and potentially reduce bleeding or thrombotic complications. The regional anesthetic component blocks nerve conduction locally, while PAI modulation may influence fibrinolysis and hemostasis in the surgical field.","oneSentence":"Regional anesthesia combined with plasminogen activator inhibitor (PAI) modulation reduces pain and inflammation at the injection site while potentially modulating fibrinolytic activity.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:04:34.272Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postoperative pain management"},{"name":"Regional anesthesia adjunct"}]},"trialDetails":[{"nctId":"NCT07327892","phase":"NA","title":"PENG Block vs PENG Plus Periarticular Injection vs Periarticular Injection in Older Adults","status":"NOT_YET_RECRUITING","sponsor":"Poznan University of Medical Sciences","startDate":"2026-02-01","conditions":"Hip Osteoarthritis, Arthropathy of Hip","enrollment":108},{"nctId":"NCT07267650","phase":"NA","title":"iPACK Block vs. Periarticular Infiltration for TKA Pain Control","status":"NOT_YET_RECRUITING","sponsor":"Turgutlu State Hospital","startDate":"2026-01-01","conditions":"Pain, Postoperative, Osteoarthritis, Knee / Osteoarthritis, Hip","enrollment":100},{"nctId":"NCT06410612","phase":"PHASE4","title":"Block and Periarticular Injection Study","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2024-03-04","conditions":"Pain, Postoperative","enrollment":160},{"nctId":"NCT06367166","phase":"NA","title":"Effects of Bioflavanoids on Vascular Wall Remodeling in Patients With Varicose Veins","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ryazan State Medical University","startDate":"2023-04-01","conditions":"Varicose Veins of Lower Limb, Varix, Vascular Diseases","enrollment":100},{"nctId":"NCT04814303","phase":"NA","title":"Impact of Adductor Canal Block on Functional Recovery","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2021-05","conditions":"Total Knee Replacement","enrollment":200},{"nctId":"NCT03691922","phase":"NA","title":"Erector Spinae Block Versus Shoulder Periarticular Anesthetic Infiltration for Arthroscopic Shoulder Surgery","status":"COMPLETED","sponsor":"McMaster University","startDate":"2019-07-06","conditions":"Arthroscopic Shoulder Surgery","enrollment":62},{"nctId":"NCT03653416","phase":"PHASE4","title":"Efficacy of Ipack Block and Surgeon's Joint Infiltration in Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Icahn School of Medicine at Mount Sinai","startDate":"2018-03-01","conditions":"Osteo Arthritis Knee","enrollment":99},{"nctId":"NCT02223364","phase":"PHASE4","title":"Peripheral Nerve Blocks vs Periarticular Local Anesthetic Injection for Total Knee Arthroplasty (TKA)","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2014-07","conditions":"Total Knee Arthroplasty","enrollment":165},{"nctId":"NCT01438437","phase":"PHASE4","title":"Trial of Ablation of Small Hepatocellular Carcinomas in Patients of Cirrhosis","status":"UNKNOWN","sponsor":"All India Institute of Medical Sciences","startDate":"2001-03","conditions":"Hepatocellular Carcinoma","enrollment":54}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["adductor canal block","periarticular injection"],"phase":"marketed","status":"active","brandName":"regional anesthesia and PAI","genericName":"regional anesthesia and PAI","companyName":"Washington University School of Medicine","companyId":"washington-university-school-of-medicine","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Regional anesthesia combined with plasminogen activator inhibitor (PAI) modulation reduces pain and inflammation at the injection site while potentially modulating fibrinolytic activity. Used for Postoperative pain management, Regional anesthesia adjunct.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}