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Pyruvic acid
Pyruvic acid is an endogenous metabolite that serves as a central hub in cellular energy metabolism, facilitating the conversion of carbohydrates, amino acids, and fats into acetyl-CoA for ATP production.
Pyruvic acid is an endogenous metabolite that serves as a central hub in cellular energy metabolism, facilitating the conversion of carbohydrates, amino acids, and fats into acetyl-CoA for ATP production. Used for Metabolic support and energy production enhancement, Potential adjunctive use in mitochondrial dysfunction.
At a glance
| Generic name | Pyruvic acid |
|---|---|
| Sponsor | Isfahan University of Medical Sciences |
| Drug class | Metabolic supplement / Organic acid |
| Modality | Small molecule |
| Therapeutic area | Metabolic disorders / General wellness |
| Phase | FDA-approved |
Mechanism of action
Pyruvic acid is a 3-carbon organic acid produced during glycolysis and plays a pivotal role in cellular respiration. It can be oxidized to acetyl-CoA to enter the citric acid cycle, transaminated to alanine, or converted to oxaloacetate for gluconeogenesis. As a marketed pharmaceutical, pyruvic acid supplementation is intended to enhance cellular energy production and metabolic efficiency.
Approved indications
- Metabolic support and energy production enhancement
- Potential adjunctive use in mitochondrial dysfunction
Common side effects
- Gastrointestinal upset
- Nausea
- Diarrhea
Key clinical trials
- Hyperpolarized Imaging in Diagnosing Participants With Glioma (PHASE1)
- Hyperpolarized Carbon-13 (13C) Pyruvate Imaging in Patients With Glioblastoma (PHASE1)
- Acquired Pyruvate Kinase Deficiency In Clonal Myeloid Neoplasms
- Studying the Biology of IDH-mutant Gliomas Via Longitudinal Observation of 2-hydroxyglutarate (2-HG) Using MR Spectroscopy (PHASE2)
- Lenvatinib Plus Pembrolizumab in Well Differentiated G3 Neuroendocrine Tumors (PHASE2)
- Genotype -Phenotype Correlation of PKLR Variants With Pyruvate Kinase, 2,3-Diphosphglycerate and Adenosine Triphosphate Activities in Red Blood Cells of People With Sickle Cell Disease
- Imaging Oxidative Metabolism and Neurotransmitter Synthesis in the Human Brain
- Metabolic Characteristics of Brain Tumors Using Hyperpolarized Carbon-13 Magnetic Resonance Spectroscopic Imaging (MRSI)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Pyruvic acid CI brief — competitive landscape report
- Pyruvic acid updates RSS · CI watch RSS
- Isfahan University of Medical Sciences portfolio CI