{"id":"pyruvic-acid","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Diarrhea"}]},"_chembl":null,"_dailymed":{"setId":"23de6b8e-7622-4ba6-89f7-37bd151687e2","title":"KIDNEX IV (GINKGO BILOBA, ALPHA-KETOGLUTARICUM ACIDUM, CITRICUM ACIDUM, FUMARICUM ACIDUM, MALICUM ACIDUM, PYRUVIC ACID, SUCCINICUM ACIDUM, ARGENTUM METALLICUM, AURUM METALLICUM, CUPRUM METALLICUM, GERMANIUM SESQUIOXIDE, MERCURIUS VIVUS, NUX VOMICA, KIDNEY (SUIS), LYMPH NODE (SUIS), NAPHTHOCHINONUM, NATRUM OXALACETICUM, PHOSPHORUS, URINARY BLADDER (SUIS), ACONITICUM ACIDUM, CIS-) LIQUID [ENERGIQUE, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Pyruvic acid is a 3-carbon organic acid produced during glycolysis and plays a pivotal role in cellular respiration. It can be oxidized to acetyl-CoA to enter the citric acid cycle, transaminated to alanine, or converted to oxaloacetate for gluconeogenesis. As a marketed pharmaceutical, pyruvic acid supplementation is intended to enhance cellular energy production and metabolic efficiency.","oneSentence":"Pyruvic acid is an endogenous metabolite that serves as a central hub in cellular energy metabolism, facilitating the conversion of carbohydrates, amino acids, and fats into acetyl-CoA for ATP production.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T02:07:22.297Z","_scrapedBy":"cloudflare-swarm","_wikipedia":{"url":"https://en.wikipedia.org/wiki/Pyruvic_acid","title":"Pyruvic acid","extract":"Pyruvic acid (CH3COCOOH) is the simplest of the alpha-keto acids, with a carboxylic acid and a ketone functional group. Pyruvate, the conjugate base, CH3COCOO−, is an intermediate in several metabolic pathways throughout the cell."},"indications":{"approved":[{"name":"Metabolic support and energy production enhancement"},{"name":"Potential adjunctive use in mitochondrial dysfunction"}]},"trialDetails":[{"nctId":"NCT03739411","phase":"PHASE1","title":"Hyperpolarized Imaging in Diagnosing Participants With Glioma","status":"RECRUITING","sponsor":"Susan Chang","startDate":"2015-12-09","conditions":"Glioma","enrollment":140},{"nctId":"NCT04019002","phase":"PHASE1","title":"Hyperpolarized Carbon-13 (13C) Pyruvate Imaging in Patients With Glioblastoma","status":"COMPLETED","sponsor":"Susan Chang","startDate":"2019-11-19","conditions":"Glioblastoma Multiforme (GBM)","enrollment":17},{"nctId":"NCT04902833","phase":"","title":"Acquired Pyruvate Kinase Deficiency In Clonal Myeloid Neoplasms","status":"ACTIVE_NOT_RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2022-02-01","conditions":"Pyruvate 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