Last reviewed · How we verify
Pycnogenol®
Pycnogenol is a plant extract rich in proanthocyanidins that acts as an antioxidant and anti-inflammatory agent, reducing oxidative stress and vascular inflammation.
Pycnogenol is a plant extract rich in proanthocyanidins that acts as an antioxidant and anti-inflammatory agent, reducing oxidative stress and vascular inflammation. Used for Chronic venous insufficiency, Diabetic retinopathy, Erectile dysfunction.
At a glance
| Generic name | Pycnogenol® |
|---|---|
| Sponsor | University of Zurich |
| Drug class | Botanical extract / Antioxidant |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular, Dermatology, Orthopedics |
| Phase | FDA-approved |
Mechanism of action
Pycnogenol, derived from French maritime pine bark, contains a complex mixture of flavonoids and proanthocyanidins that scavenge free radicals and inhibit inflammatory pathways. It enhances endothelial function by increasing nitric oxide availability and improving blood flow, while also stabilizing collagen and reducing vascular permeability through cross-linking of structural proteins.
Approved indications
- Chronic venous insufficiency
- Diabetic retinopathy
- Erectile dysfunction
- Osteoarthritis
- Skin health and anti-aging
Common side effects
- Gastrointestinal upset
- Headache
- Dizziness
Key clinical trials
- Evaluation of Pine Bark Extract for Anti-fatigue Ergogenic Properties (NA)
- Evaluation of the Ergogenic Properties of Hesperetin on Exercise-induced Fatigue (NA)
- Pycnogenol® in Post-COVID-19 Condition (PHASE3)
- Impact of Pycnogenol® on Gingival Inflammation (NA)
- Improving Effects of Fish Oil Combined With Pine Bark Extract on Cognitive Decline (NA)
- Effect of Oligopin® on Skin Ageing (NA)
- Effect of Oligopin® on Blood Pressure. (NA)
- A Study Comparing Estradiol Vaginal Cream to Estrace® Cream in Females With Atrophic Vaginitis (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |